Highlights
– Autopsy study of five aducanumab-treated Alzheimer’s cases shows disproportionate clearance of Aβ from superficial cortical layer I with limited clearance in deeper layers, despite PET Centiloid reductions of up to 81%.
– Regions corresponding to ARIA on MRI contained microinfarcts with haemosiderin, complement activation, and CD68-positive vessel-wall changes arising from Aβ-laden leptomeningeal and penetrating vessels.
