Posted innews
コンドロカルシン症は新規膝関節症の発症を予測する
2つの大規模縦断研究は、基線時のコンドロカルシン症が長期フォローアップ中に放射線学的に確認された膝関節症の発症確率を約75%上昇させることを示しています。これは、カルシウム結晶沈着がOAの病態生理に寄与している可能性を示唆しています。
Posted innews Orthopedics Rehabilitation Medicine
Two-thirds of ACL-injured Patients Avoid Surgery at 2 Years: Nationwide Registry Shows Rehab-first Strategy Often Works but Younger, Pivoting-sport Athletes and Meniscal Tears Predict Delayed Reconstruction
A Norwegian registry study reports that 63% of patients with primary ACL injury initially managed non‑operatively remained non‑operative at two years; younger age, participation in pivoting sports and baseline meniscal injury increased risk of delayed ACL reconstruction, while 2‑year KOOS scores were similar.
Posted inAI news Orthopedics
Digital‑Twin Decision Aid for Knee Osteoarthritis Improves Decision Quality and 6‑Month Function: Randomized Trial Results
An AI-enabled decision aid that generated patient-specific digital twins improved decision quality, reduced decisional conflict and regret, and produced better 6–9 month knee function versus education alone in patients considering total knee arthroplasty.
Posted inDiabetes & Endocrinology Neurology news
SGLT2 Inhibitors Linked to Lower Parkinson’s Disease Risk Than Metformin in Type 2 Diabetes: Large Real‑World TriNetX Study Signals Class Neuroprotection
A 20‑year TriNetX analysis of 913,428 T2DM patients found SGLT2 inhibitor use associated with a 28% lower Parkinson’s disease risk versus metformin (aHR 0.72), suggesting possible superior neuroprotection and prompting need for prospective confirmation.
Posted inDermatology Diabetes & Endocrinology news
SGLT2 Inhibitors Linked to Lower Risk of New-Onset Atopic Dermatitis in People with Type 2 Diabetes
A nationwide Taiwanese active-comparator cohort found SGLT2 inhibitor use was associated with a lower incidence of new-onset atopic dermatitis compared with DPP‑4 inhibitors; the effect persisted across sensitivity analyses, showed a dose-response relation and was stronger in men.
Posted inDermatology Diabetes & Endocrinology news
SGLT2 Inhibitors Associated with Lower Risk of New-Onset Atopic Dermatitis in People with Type 2 Diabetes: Nationwide Active-Comparator Cohort Study
A Taiwanese nationwide cohort study found SGLT2 inhibitor use linked to a lower incidence of new-onset atopic dermatitis versus DPP4 inhibitors (IPTW-adjusted HR 0.847), with a dose-response effect and stronger protection in men.
Posted inDiabetes & Endocrinology news Rheumatology
SGLT-2 Inhibitors and Autoimmune Rheumatic Disease Risk Reduction in Type 2 Diabetes: Insights from a Korean Nationwide Cohort
A large South Korean cohort study suggests that sodium-glucose cotransporter-2 (SGLT-2) inhibitors reduce the incidence of autoimmune rheumatic diseases by 11% compared to sulfonylureas in adults with type 2 diabetes, indicating potential immunomodulatory benefits of SGLT-2 inhibitors beyond glycemic control.
Posted inDiabetes & Endocrinology news Ophthalmology
Long-Term Progression and Risk Factors of Diabetic Retinopathy in Type 2 Diabetes: Insights from the Skaraborg Cohort in Sweden
This cohort study tracks diabetic retinopathy incidence over 24 years in type 2 diabetes patients, highlighting the impact of glycemic control and hypertension on disease progression.
Posted inInfectious Diseases news Pediatrics
Optimizing Blood Culture Use in Pediatric Infections: Insights from the ACORN2 Surveillance Network in Africa and Asia
This study identifies clinical and demographic factors associated with positive blood cultures in hospitalized children across nine African and Asian countries, aiming to improve diagnostic stewardship amidst resource constraints.
Posted inHematology-Oncology news
CM313, a Novel Anti-CD38 Monoclonal Antibody, Demonstrates Promising Efficacy and Safety in Persistent or Chronic Primary Immune Thrombocytopenia: Insights from a Phase 2 Randomized Trial
The phase 2 trial shows that CM313 significantly improves platelet response rates and duration with manageable safety in adults with persistent or chronic primary immune thrombocytopenia.
Posted inCardiology news Public Health
Early Life Sugar Restriction and Its Lasting Impact on Adult Cardiovascular Health: Insights from a Natural Experiment
Exposure to sugar rationing during the first 1000 days after conception correlates with significantly reduced cardiovascular disease risk and improved cardiac function decades later, highlighting early nutritional influences on long-term heart health.
Evaluating Self-Collected Urine and Vaginal Samples for HPV Genotyping in Cervical Cancer Screening Among Japanese Women
This study assesses the feasibility and performance of using self-collected urine and vaginal samples with the BD Onclarity® HPV assay for cervical cancer screening in Japanese women with abnormal cytology, highlighting concordance and sensitivity metrics compared to clinician-collected cervical samples.
Posted innews OB/GYN & Women's Health Public Health
Long-Term Effectiveness of HPV Screen-and-Treat Strategy Versus Cytology in Cervical Cancer Screening: Insights from El Salvador’s CAPE Program
A 5-year follow-up study in El Salvador demonstrates that primary HPV screen-and-treat significantly reduces CIN2+ detection and HPV positivity compared to cytology, supporting extended screening intervals in low-resource settings.
Posted innews Psychiatry Public Health
Understanding Sex- and Age-Specific Suicide Risk Indicators: Insights from a Large Swedish Case-Control Study
This Swedish population-based study highlights how suicide risk indicators vary by sex and age, showing males and older adults exhibit fewer, but often higher absolute risk indicators, underscoring the need for tailored suicide prevention strategies.
Prophylactic Antibiotics in Episiotomy and Second Degree Tears: Insights from the REPAIR Trial
The REPAIR study demonstrates that prophylactic antibiotics reduce clinically relevant wound complications after episiotomy or second degree tears, highlighting a potential role for antibiotics in postpartum care.
Comparative Efficacy and Safety of Tirzepatide, Semaglutide, and Liraglutide for Obesity Management: A Critical Review of Recent Cochrane Evidence
This article critically compares the efficacy, safety, and long-term outcomes of tirzepatide, semaglutide, and liraglutide for the treatment of obesity based on recent Cochrane systematic reviews, highlighting differences in weight loss, adverse events, cardiovascular outcomes, and evidence certainty.
Patritumab Deruxtecan (HER3-DXd) Shows Promising Activity in Breast Cancer Patients with Active Brain Metastases: Insights from the TUXEDO-3 Phase 2 Trial
The TUXEDO-3 trial demonstrates that patritumab deruxtecan, a HER3-targeted antibody-drug conjugate, offers clinical benefit and a manageable safety profile in metastatic breast cancer patients with active brain metastases.
Posted innews Nursing & care Orthopedics
Preventing Falls in Care Homes: What the 2025 Cochrane Review Now Recommends
An evidence-based synthesis of the 2025 Cochrane review on fall-prevention in care facilities: which interventions work, for whom, and how to implement them in practice.
Posted innews OB/GYN & Women's Health Public Health
Review for Cervical Cancer Screening
A comprehensive 2025 systematic review informing the Canadian Task Force finds cytology remains effective into the 60s, HPV-based strategies detect more precursors but increase colposcopy and false positives, and self-sampling improves uptake in underscreened people.
European Prostate Cancer Screening After 23 Years: Sustained Mortality Reduction and Improved Harm-Benefit Profile
The 23-year follow-up of the ERSPC confirms that PSA screening reduces prostate cancer mortality by 13%, with an improved harm-benefit ratio, supporting risk-based screening strategies to optimize outcomes.