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Extending the Therapeutic Window: Alteplase Use 4.5 to 24 Hours After Ischemic Stroke in the HOPE Trial
Posted inClinical Updates Wellness & Lifestyle

Extending the Therapeutic Window: Alteplase Use 4.5 to 24 Hours After Ischemic Stroke in the HOPE Trial

Posted by By MedXY 09/03/2025
The HOPE trial demonstrates that intravenous alteplase administered 4.5 to 24 hours after ischemic stroke onset improves functional independence in patients with salvageable brain tissue, despite increased risk of symptomatic intracranial hemorrhage.
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Thrombolysis Before Thrombectomy May Raise ICH Risk After Stroke: A Comprehensive Review of Recent Evidence
Posted inNeurology Specialties Wellness & Lifestyle

Thrombolysis Before Thrombectomy May Raise ICH Risk After Stroke: A Comprehensive Review of Recent Evidence

Posted by By MedXY 08/19/2025
A meta-analysis of over 2000 stroke patients found that intravenous thrombolysis (IVT) before endovascular treatment (EVT) modestly increases intracranial hemorrhage (ICH) risk, especially in patients with elevated glucose and blood pressure, though functional benefits may still outweigh risks.
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