Posted inCardiology news
Reticulated Platelets Drive Prothrombotic Signalling in Coronary Artery Disease — GPVI and PI3K Identified as Actionable Targets
A multidimensional study of 95 CAD patients shows that RNA-rich reticulated platelets exhibit a distinct prothrombotic transcriptomic and proteomic signature with upregulated GPVI and PI3K signalling; GPVI and PI3K inhibition reduced RP-driven thrombogenicity ex vivo.