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osteosarcoma

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Denosumab Shows Insufficient Activity in Recurrent Osteosarcoma: Results from a Children’s Oncology Group Phase 2 Trial
Posted innews Oncology Pediatrics

Denosumab Shows Insufficient Activity in Recurrent Osteosarcoma: Results from a Children’s Oncology Group Phase 2 Trial

Posted by MedXY By MedXY 01/11/2026
A Phase 2 trial by the Children's Oncology Group found that denosumab, despite its success in other bone-related conditions, failed to meet efficacy benchmarks for recurrent or refractory osteosarcoma, showing no objective responses in patients with measurable disease.
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Posted innews Oncology

SMARCAL1 Emerges as a Novel Osteosarcoma Predisposition Gene: Large Study Validates DNA Repair Variation in Pediatric Cancer Risk

Posted by Zhang Paul By Zhang Paul 12/10/2025
A large case-control analysis of 189 DNA damage response genes in nearly 6,000 children with cancer identifies enrichment of pathogenic variants in DDR genes and nominates SMARCAL1 as a replicated osteosarcoma predisposition gene
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