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Targeting S-Nitrosylated PKM2: A Novel Therapeutic Frontier in Cardiac Fibrosis and Mitochondrial Dynamics
Posted inCardiology Clinical Updates news

Targeting S-Nitrosylated PKM2: A Novel Therapeutic Frontier in Cardiac Fibrosis and Mitochondrial Dynamics

Posted by MedXY By MedXY 03/03/2026
Recent evidence identifies S-nitrosylation of Pyruvate Kinase M2 (PKM2) as a specific driver of cardiac fibrosis, suggesting that activating PKM2 with drugs like mitapivat could provide a long-sought therapeutic approach for heart failure patients.
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Mitapivat Offers New Hope for Adults with Non-Transfusion-Dependent α- and β-Thalassaemia: Results from the Phase 3 ENERGIZE Trial
Posted inClinical Updates Hematology-Oncology news Specialties

Mitapivat Offers New Hope for Adults with Non-Transfusion-Dependent α- and β-Thalassaemia: Results from the Phase 3 ENERGIZE Trial

Posted by MedXY By MedXY 08/02/2025
Mitapivat significantly improves haemoglobin levels in adults with non-transfusion-dependent α- or β-thalassaemia, offering a promising oral therapeutic option with manageable safety profile.
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