metabolomics – Medxy AI

Integrating Metabolomics and Polygenics with SCORE2: A New Frontier in Cardiovascular Risk Stratification

By MedXY 01/05/2026

A large-scale UK Biobank study demonstrates that combining NMR metabolomics, polygenic risk scores, and clinical biomarkers with SCORE2 significantly enhances cardiovascular risk prediction, potentially doubling the number of prevented events through improved clinical reclassification.

Cardiology news Public Health

Synergistic Integration of Metabolomics and Polygenic Scores Doubles the Impact of Cardiovascular Risk Prediction Models

By MedXY 01/05/2026

A large-scale UK Biobank study demonstrates that combining NMR metabolomics and polygenic risk scores with the SCORE2 framework significantly improves cardiovascular risk discrimination, potentially doubling the number of preventable events in population-wide screening programs.

Cardiology Internal Medicine news

N-Palmitoyl Glutamine: A Novel Molecular Link Between Exercise, Mitochondrial Efficiency, and Human Longevity

By MedXY 12/25/2025

A groundbreaking study identifies N-palmitoyl glutamine (NPG) as a key molecular transducer of cardiorespiratory fitness. NPG correlates with VO2max, increases with exercise training, predicts lower mortality, and directly enhances mitochondrial function, offering a potential therapeutic target for cardiometabolic health.

Gastroenterology Internal Medicine news

Gut Microbiota Dysbiosis in Cirrhotic Portal Hypertension: Unraveling Microbial Contributions to Disease Progression

By MedXY 10/09/2025

Altered gut microbiota composition and metabolism exacerbate cirrhotic portal hypertension, highlighting potential microbiome-targeted therapies to mitigate disease progression.

Neurology Pediatrics Psychiatry Specialties

Unraveling ADHD: Gut Microbial Signatures and the Role of SCFA Deficiency in Symptom Pathogenesis

By MedXY 09/29/2025

Recent research reveals distinct gut microbial and metabolic profiles linked to ADHD symptoms, highlighting short-chain fatty acid deficiency as a key mechanism driving hyperactivity and inattention.

Clinical Updates Family Medicine & Nutrition Orthopedics Specialties

Personalized Anti-Inflammatory Diet Modulates Gut Microbiome and Metabolome to Alleviate Osteoarthritis Pain

By MedXY 09/16/2025

A 4-week anti-inflammatory dietary intervention in knee osteoarthritis patients led to targeted shifts in gut microbiota and metabolite profiles associated with significant pain reduction, highlighting the potential of microbiome-informed nutritional strategies for OA management.

Clinical Updates Diabetes & Endocrinology news Specialties

Recent Advances in Dihydroberberine Research: Pharmacokinetics, Mechanisms, and Clinical Potential

By MedXY 08/24/2025

This review synthesizes the latest 5-year evidence on dihydroberberine, highlighting improved bioavailability over berberine, mechanistic insights from metabolic and network pharmacology studies, and its promising clinical applications in metabolic and respiratory diseases.

Diabetes & Endocrinology news Specialties

Predicting Long-Term Mortality: Insights from a Multi-Metabolite Signature in the PREDIMED Trial

By MedXY 08/11/2025

A study identified a robust plasma multi-metabolite signature that predicts long-term all-cause mortality in participants from the PREDIMED trial and several US cohorts, providing new insights into metabolic biomarkers.