Large Vessel Occlusion

Standard-Dose Tenecteplase vs Low-Dose Alteplase for Acute Ischemic Stroke From Large-Vessel Occlusion: A Randomized Clinical Trial

By MedXY 06/03/2026

In a randomized trial of large-vessel-occlusion stroke, standard-dose tenecteplase improved early reperfusion before thrombectomy compared with low-dose alteplase, with similar safety and functional outcomes.

Neurology news

Standard-Dose Tenecteplase vs Low-Dose Alteplase for Acute Ischemic Stroke From Large-Vessel Occlusion: A Randomized Clinical Trial

By MedXY 06/03/2026

In patients with large-vessel-occlusion stroke undergoing thrombectomy, standard-dose tenecteplase achieved more early reperfusion than low-dose alteplase, with similar safety and functional outcomes.

Cardiology Clinical Updates news

Optimizing the Referral Pathway for Mechanical Thrombectomy: Evidence-Based Perspectives on Mothership vs. Drip-and-Ship Models

By MedXY 05/09/2026

This review synthesizes recent evidence comparing 'mothership' and 'drip-and-ship' strategies in acute ischemic stroke, highlighting functional benefits of direct transport and the critical 43-minute delay threshold.

Emergency Medicine Neurology news

Earlier IV Thrombolysis Before Thrombectomy Was Linked to Better In-Hospital Stroke Outcomes in RES-Q

By MedXY 05/07/2026

A large multinational RES-Q registry analysis suggests that the benefit of bridging thrombolysis before thrombectomy is greatest when treatment starts very early, with attenuation after 150 minutes.

Neurology news

Giving Thrombolysis Late — Before Transfer for Thrombectomy — May Improve Outcomes in AIS-LVO: Evidence from a 20-Center French Cohort

By MedXY 12/09/2025

A multicenter retrospective cohort found that IV thrombolysis started beyond 4.5 hours and before interhospital transfer for EVT was associated with higher rates of spontaneous recanalization during transfer and better 3‑month functional outcomes without increased hemorrhage.

Clinical Updates Neurology Specialties

Optimizing Head Positioning in Large Vessel Occlusion Stroke Before Thrombectomy: Evidence from a Randomized Clinical Trial

By MedXY 09/11/2025

A recent randomized clinical trial demonstrates that 0° head-of-bed positioning prior to thrombectomy in patients with large vessel occlusion stroke preserves neurological stability and reduces mortality compared to the conventional 30° elevation.

Neurology news Specialties

SUMMIT MAX Trial Validates Super Large Bore HiPoint System for Effective and Safe Aspiration Thrombectomy in Large Vessel Occlusion Stroke

By MedXY 08/17/2025

The SUMMIT MAX randomized trial demonstrates that the super large bore HiPoint reperfusion system is noninferior to the Vecta system in reperfusion success and safety for acute ischemic stroke due to large vessel occlusion.