knee osteoarthritis

T2 Mapping Detects BMI-Linked Cartilage Changes and Lateral Compartment Signal Differences in Population-Based Knee OA

By MedXY 11/02/2025

In a large population-based sample, cartilage T2 relaxation times correlated with BMI and were higher in knees with MRI-defined osteoarthritis, particularly in lateral cartilage subregions; T2 did not reflect patient-reported symptoms.

news Orthopedics Rheumatology

Partitioning Knee Osteoarthritis Genetic Risk by BMI Association Clarifies Prediction and Mechanisms

By MedXY 11/02/2025

Partitioning a knee osteoarthritis polygenic score into BMI-associated and BMI-independent components clarifies genetic contributions, improves interpretability, and offers a path to tailored prediction and prevention.

news OB/GYN & Women’s Health Orthopedics Rehabilitation Medicine

Higher Endogenous Testosterone Is Associated with Lower Risk of Knee Osteoarthritis in Women

By MedXY 11/02/2025

In a large UK Biobank cohort, higher circulating testosterone was associated with lower prevalent and incident knee osteoarthritis (KOA) in middle-aged and older women, while SHBG and estradiol showed no clear associations.

news Orthopedics Rheumatology

Targeting Modifiable Risks to Prevent Knee Osteoarthritis

By MedXY 11/01/2025

A large systematic review identified prior knee injury, older age, and high bone mineral density as predictors of incident radiographic knee osteoarthritis; overweight/obesity and prior injury explained ~14% of cases—highlighting prevention priorities across the life course.

news Orthopedics Rheumatology

Physical Activity and Risk of Knee Replacement in Radiographic Osteoarthritis

By MedXY 11/01/2025

In a 9-year OAI cohort analysis, baseline self-reported moderate physical activity was linked to lower knee replacement risk in KL grade 2 but to higher risk in KL >2; high activity showed no clear effect. Results support severity-tailored activity advice and highlight limitations of single self-report measures.

news Orthopedics Rheumatology

Baseline Sarcopenia Predicts Faster Knee Osteoarthritis Progression and Much Higher Risk of Knee Replacement

By MedXY 11/01/2025

In a longitudinal analysis of 4,316 Osteoarthritis Initiative participants, baseline sarcopenia screened by SARC-F and chair-stand testing was associated with accelerated radiographic and symptomatic knee OA progression over 24–48 months and substantially higher risk of subsequent knee replacement.

Clinical Updates Diabetes & Endocrinology news Orthopedics

Metformin in Knee Osteoarthritis: Evaluating Its Role in Pain Relief and Disease Modification

By MedXY 11/01/2025

Emerging evidence supports metformin's modest pain-relieving effects and potential disease-modifying properties in knee osteoarthritis patients with overweight or obesity, warranting further investigation through larger trials.

Clinical Updates Family Medicine & Nutrition news Orthopedics

Online Unsupervised Tai Chi Intervention for Knee Osteoarthritis: Insights from the RETREAT Randomized Clinical Trial and Systematic Reviews

By MedXY 10/29/2025

This review synthesizes evidence from the RETREAT RCT and past systematic reviews, highlighting that an unsupervised online Tai Chi program significantly improves knee pain and function in knee osteoarthritis, providing a scalable, accessible exercise option.

news Orthopedics Rheumatology

Evaluating Pilates for Knee Osteoarthritis: Efficacy, Safety, and Clinical Insights from Recent Meta-Analysis

By MedXY 10/11/2025

A systematic review and meta-analysis of RCTs indicates Pilates may improve pain and function in knee osteoarthritis patients, though evidence quality is low and safety data insufficient. Caution is warranted in interpreting results, highlighting a need for standardized future research.

news Orthopedics Rheumatology

Evaluating Implementation Strategies for Group Physical Therapy in Knee Osteoarthritis: Insights from a Cluster Randomized Clinical Trial

By MedXY 10/05/2025

A cluster randomized trial found that enhanced implementation support for group physical therapy in knee osteoarthritis did not significantly improve patient enrollment compared to foundational support, highlighting challenges in fostering referrals despite high therapy attendance.

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Personalized Gait Retraining: A Promising Conservative Approach to Medial Knee Osteoarthritis

By MedXY 09/01/2025

A randomized trial shows that personalized foot progression angle modifications significantly reduce medial knee pain and slow cartilage degeneration in medial compartment knee osteoarthritis.

Orthopedics Specialties

Enhanced Relief in Knee Osteoarthritis: Synergistic Effects of tDCS and Acupuncture on Brain Connectivity and Clinical Outcomes

By MedXY 08/26/2025

A randomized controlled trial demonstrates that combining transcranial direct current stimulation with acupuncture significantly improves pain and dysfunction in knee osteoarthritis patients by modulating brain network connectivity.

Clinical Updates news Orthopedics Specialties

Evaluating the Role of Estrogen Replacement Therapy Combined with Resistance Exercise in Older Women with Knee Osteoarthritis: Insights from a Randomised Clinical Trial

By MedXY 08/24/2025

This trial assessed the additive effects of low-dose transdermal estrogen replacement therapy combined with resistance exercise in women aged 65+ with knee osteoarthritis, finding no overall significant benefit but suggesting potential improvements in early-stage disease and mental health.

Clinical Updates news Orthopedics Specialties

Curcumin’s Impact on Serum Inflammatory Biomarkers in Knee Osteoarthritis: Evidence from a Systematic Review and Meta-Analysis

By MedXY 08/06/2025

A systematic review and meta-analysis found that curcumin supplementation significantly reduces serum CRP and TNF-alpha in patients with knee osteoarthritis, but not other inflammatory biomarkers.

Clinical Updates Medical News Orthopedics Specialties

Medial Opening Wedge High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis: Evidence from a Randomized Controlled Trial

By MedXY 07/31/2025

A randomized trial demonstrates that medial opening wedge high tibial osteotomy (HTO) slows cartilage loss and improves symptoms in patients with medial compartment knee osteoarthritis and varus alignment, supporting its role as a joint-preserving intervention.

Clinical Updates Orthopedics Specialties

High Tibial Osteotomy May Slow Knee Osteoarthritis Progression in Bowlegged Patients: Clinical Insights from a Randomized Trial

By MedXY 07/30/2025

High tibial osteotomy (HTO) slows cartilage loss and improves pain and function in bowlegged patients with medial knee osteoarthritis compared to nonsurgical management, according to a new randomized trial.