inflammation – Medxy AI

Unpacking the ‘Weathering’ Hypothesis: How Cumulative Lifespan Stress and Inflammation Drive Racial Disparities in Mortality

By MedXY 02/10/2026

A longitudinal study identifies that cumulative lifetime stress and systemic inflammation mediate nearly 50% of the mortality gap between Black and White adults, providing a biological link between structural inequity and premature death.

Family Medicine & Nutrition Internal Medicine news Rheumatology

The Tart Cherry Revolution: A Deep Dive into the Science of Longevity, Recovery, and Restorative Sleep

By MedXY 02/07/2026

This article explores the multi-faceted health benefits of tart cherry juice, from its potent anti-inflammatory properties to its role in enhancing sleep and cardiovascular health, supported by the latest clinical research.

Neurology news Radiology

Atorvastatin Attenuates Aneurysmal Wall Inflammation in Vertebrobasilar Dissecting Aneurysms: Insights from a Randomized Controlled Trial

By MedXY 01/21/2026

A randomized controlled trial demonstrates that 6-month atorvastatin treatment significantly reduces aneurysm wall enhancement and systemic inflammatory markers in patients with unruptured vertebrobasilar dissecting aneurysms, potentially offering a non-invasive stabilizing therapy for these high-risk lesions.

Cardiology Internal Medicine news

Beyond Standard Risk Factors: High-Sensitivity C-Reactive Protein as a Critical Driver of Cardiovascular Risk Prediction

By MedXY 01/05/2026

Recent large-scale studies demonstrate that high-sensitivity C-reactive protein (hsCRP) is a potent, stable predictor of cardiovascular events, even in individuals without traditional risk factors. Despite its clinical utility in improving risk reclassification, barriers to widespread adoption in clinical practice remain.

Infectious Diseases Internal Medicine news

Colchicine for Long COVID: Randomized Trial Finds No Benefit in Functional Recovery or Inflammatory Resolution

By MedXY 01/01/2026

A multi-center randomized clinical trial published in JAMA Internal Medicine demonstrates that colchicine, despite its potent anti-inflammatory properties, fails to improve 6-minute walk test distances or inflammatory markers in patients suffering from Long COVID, highlighting the complexity of the condition's pathogenesis.

Diabetes & Endocrinology news

Dietary Inflammatory and Insulinemic Potentials Drive Type 2 Diabetes Progression Following Gestational Diabetes: Insights from the Nurses’ Health Study II

By MedXY 12/30/2025

A prospective study of 4,318 women reveals that dietary patterns promoting inflammation and hyperinsulinemia significantly elevate the risk of progressing from gestational diabetes to type 2 diabetes, with BMI serving as a primary mediator of this metabolic transition.

Critical Care news Respiratory

Inflammatory Subphenotypes in COVID-19 ARDS Exhibit High Temporal Stability: Insights from the ICAR Trial

By MedXY 12/27/2025

A reanalysis of the ICAR trial reveals that ARDS inflammatory subphenotypes remain remarkably stable over 28 days. The hyperinflammatory profile is linked to higher mortality and distinct biomarkers, with Bayesian modeling showing minimal transitions between phenotypes over time.

Cardiology Internal Medicine news

Calprotectin: A Mechanistically Informed Biomarker for Predicting Atherosclerotic Cardiovascular Disease

By MedXY 12/24/2025

A longitudinal study from the Dallas Heart Study identifies calprotectin as a significant, independent predictor of ASCVD events, linking neutrophil activation to endothelial dysfunction and increased cardiovascular risk across diverse populations.

news Psychiatry Radiology

Mapping the Neuro-Immune Divide: Distinct Brain-Blood Signatures Distinguish Early Depression from Psychosis

By MedXY 12/24/2025

A large-scale multicenter study identifies unique multivariate patterns of peripheral inflammation and brain structure that differentiate early-stage depression and psychosis, highlighting the influence of childhood trauma and cognitive performance on these distinct neurobiological signatures.

Cardiology Clinical Updates news

Cellular Adhesion Molecules as Prognostic Biomarkers and Therapeutic Insights in Chronic Heart Failure: Integrative Review Emphasizing DAPA-HF Findings

By MedXY 12/03/2025

Elevated VCAM-1 levels correlate with worse outcomes in chronic HFrEF, independent of conventional markers; dapagliflozin’s benefits are consistent across VCAM-1 levels, highlighting inflammatory pathways as therapeutic targets.

Cardiology news

LOX‑1 Blockade After MI Reduced sLOX‑1 and IL‑6 but Not Coronary Noncalcified Plaque: Lessons from GOLDILOX‑TIMI 69

By MedXY 11/12/2025

In a randomized phase 2 trial, the anti‑LOX‑1 antibody MEDI6570 lowered circulating sLOX‑1 and IL‑6 but failed to reduce noncalcified coronary plaque volume versus placebo in post‑MI patients with residual inflammation.

Diabetes & Endocrinology Neurology news

Obesity Alters Symptom Trajectory and Inflammatory Signatures after Sport-Related Concussion: the NCAA‑DoD CARE Consortium

By MedXY 11/04/2025

In a large prospective cohort, obese BMI (≥30) was associated with worse post-concussion neurocognitive outcomes and a persistently proinflammatory blood biomarker profile, despite fewer baseline symptoms. Findings suggest obesity modifies clinical recovery and biological response after sport-related concussion.

Allergy & Immunology news Pediatrics Respiratory

Unveiling Diverse Inflammatory Pathways in Residual Pediatric Asthma Exacerbations Under Mepolizumab Therapy

By MedXY 10/27/2025

This study reveals multiple distinct molecular mechanisms, including epithelial and macrophage pathways, that contribute to residual asthma exacerbations in children treated with mepolizumab, highlighting the complexity of airway inflammation.

Gastroenterology news Oncology

Microbial Metabolism Dysfunction and Its Impact on Liver Injury After TACE in Hepatocellular Carcinoma

By MedXY 10/27/2025

This review explores how gut microbiota disturbances, especially L. reuteri and its metabolite ILA, influence post-TACE liver injury and prognosis in HCC patients, highlighting potential microbiota-targeted therapies.

Allergy & Immunology Otorhinolaryngology

Gender Differences in Chronic Rhinosinusitis: Insights into Diagnosis and Biomarkers

By MedXY 10/24/2025

This study explores how biological sex influences CRS diagnosis and inflammatory biomarkers, revealing sex-specific patterns that could inform personalized treatment.

Cardiology news

Low-Dose Colchicine in Acute Myocardial Infarction: Insights from an Updated Meta-Analysis

By MedXY 10/12/2025

An updated meta-analysis evaluates the effects of 0.5 mg colchicine on clinical outcomes after acute myocardial infarction, showing reduced hospital readmission but increased diarrhea risk without significant impact on major cardiovascular events.

Neurology news Public Health

How Poor Sleep Accelerates Brain Aging: The Role of Inflammation and What You Can Do

By MedXY 10/08/2025

New research links poor sleep quality in middle-aged and older adults to accelerated brain aging, with inflammation playing a key role. Improving sleep may help slow cognitive decline and promote brain health.

Dermatology Family Medicine & Nutrition Specialties

Mediterranean Diet as Adjunct Therapy in Psoriasis: Insights from the MEDIPSO Randomized Clinical Trial

By MedXY 09/28/2025

A 16-week Mediterranean diet intervention significantly reduced psoriasis severity and improved metabolic markers in patients with mild to moderate disease, suggesting diet’s role as adjunctive therapy in psoriasis management.

Clinical Updates Family Medicine & Nutrition Specialties

Mediterranean Diet Outperforms Other Dietary Patterns in Reducing Mortality via Inflammatory Pathways: Insights from a Causal Inference Analysis

By MedXY 09/17/2025

A causal analysis of nine dietary patterns reveals the Mediterranean diet as most effective in reducing all-cause and cardiovascular mortality, primarily through modulation of inflammatory biomarkers such as CRP, NPR, and SII.

Diabetes & Endocrinology Family Medicine & Nutrition news Specialties

Hydroxytyrosol Supplementation Enhances Antioxidant and Anti-Inflammatory Status in Overweight Prediabetic Adults: Insights from a Randomized Controlled Trial

By MedXY 09/17/2025

A 16-week randomized trial demonstrates that daily hydroxytyrosol supplementation significantly reduces oxidative stress and inflammatory markers in overweight individuals with prediabetes, highlighting its potential in preventing aging-related diseases.