family history – Medxy AI

Family History Misses Actionable Germline Variants in Many Ovarian Cancer Patients Over 70

By MedXY 05/13/2026

A large real-world registry study shows that ovarian cancer patients aged 70 and older still carry clinically actionable germline variants, often without a reported family history, supporting broader age-inclusive genetic testing.

news Oncology Urology

Refining Prostate Cancer Risk Prediction in Men of African Ancestry: Integrating Pathogenic Variants, Polygenic Scores, and Family History

By MedXY 12/17/2025

This study identifies key germline variants and demonstrates how combining genetic data with family history improves personalized prostate cancer risk assessment in men of African ancestry, guiding future screening strategies.

news Oncology

Quantifying Breast Cancer Risk: The Impact of Pathogenic Variants and Family History in US Women

By MedXY 10/10/2025

This study evaluates cumulative breast cancer risks among US women based on pathogenic variant status and family history, revealing significant risk stratification that informs personalized screening and prevention.