elderly – Medxy AI

Statin Therapy in Older Adults with Chronic Kidney Disease: Primary Prevention of Cardiovascular Disease and Safety Profile in Hypercholesterolemic Patients

By MedXY 10/20/2025

This study demonstrates that statin therapy effectively reduces cardiovascular risk and all-cause mortality in older adults with chronic kidney disease and hypercholesterolemia, without increasing major adverse events, even in very elderly patients.

Internal Medicine Psychiatry Specialties

Comparative Effectiveness of Long-Acting Injectable Versus Oral Antipsychotics in Older Adults with Schizophrenia: Insights from Hong Kong’s Population-Based Study

By MedXY 10/18/2025

This study compares long-acting injectable to oral antipsychotics in older schizophrenia patients, highlighting benefits in relapse prevention and mortality reduction, with specific considerations for adverse effects.

Internal Medicine Neurology news

Aspirin Use in Older Adults: Insights from the ASPREE-XT Study on Healthy Lifespan

By MedXY 10/07/2025

Extended follow-up from the ASPREE-XT study shows low-dose aspirin does not improve healthy lifespan—defined as survival free of dementia, persistent disability, or death—in healthy older adults, and its risks include increased major hemorrhagic events.

Cardiology news Public Health Respiratory Specialties

Bivalent RSV Prefusion F Protein Vaccine: A Potential Strategy to Reduce Cardiovascular Hospitalizations in Older Adults

By MedXY 09/01/2025

The DAN-RSV trial demonstrates that RSV vaccination significantly lowers all-cause cardiorespiratory hospitalizations among older adults, suggesting vaccines may reduce infection-triggered cardiovascular complications and benefit chronic disease management.

Cardiology news Specialties

Reevaluating Antihypertensive Therapy in Frail Elderly Nursing Home Residents: Insights from the RETREAT-FRAIL Trial

By MedXY 08/30/2025

The RETREAT-FRAIL trial found no survival benefit from progressively reducing antihypertensive medications in frail nursing home residents aged ≥80 with controlled blood pressure, supporting individualized treatment strategies.

Clinical Updates Oncology Specialties

No Added Survival Benefit from Adjuvant Chemotherapy in Older Women with Genomically High-Risk Hormone Receptor-Positive Breast Cancer: Results from the ASTER 70s Trial

By MedXY 08/07/2025

The ASTER 70s trial found that adding chemotherapy to hormonotherapy did not improve survival but increased toxicity in women aged 70+ with high-risk ER+/HER2- breast cancer.

Cardiology Clinical Updates news Public Health Specialties

High-Dose and Adjuvanted Flu Vaccines Offer Equivalent Protection for Older US Adults

By MedXY 07/31/2025

A large US study finds adjuvanted and high-dose quadrivalent influenza vaccines provide comparable protection against lab-confirmed flu in seniors, supporting current immunization guidelines.

Clinical Updates news Oncology Orthopedics Specialties

Inconsistent Bone Health Management in Older Women With Breast Cancer: Insights From the Age Gap Study

By MedXY 07/31/2025

Significant variation exists in bone health management for older women receiving endocrine therapy for breast cancer, highlighting the need for standardized care.

Clinical Updates Diabetes & Endocrinology news Specialties

GLP-1 Receptor Agonists and Dementia Risk in Older Adults With Type 2 Diabetes: Insights From a Target Trial Emulation

By MedXY 07/31/2025

A large-scale emulated trial found no clear overall reduction in dementia risk with GLP-1 receptor agonists versus DPP-4 inhibitors in older adults with type 2 diabetes, though age-specific effects warrant further investigation.