biomarkers – Medxy AI

Biomarker-Guided ABC-AF Risk Scores in Atrial Fibrillation: Insights from a Large Multicenter Randomized Trial

By MedXY 09/06/2025

A biomarker-based ABC-AF risk score-guided treatment did not improve stroke or death outcomes versus standard care in atrial fibrillation, underscoring the need for prospective validation of precision medicine tools before clinical implementation.

Clinical Updates Wellness & Lifestyle

Precision Psychiatry Roadmap: Integrating Biology into Mental Disorder Classification and Treatment

By MedXY 08/30/2025

Mental disorders currently diagnosed symptomatically can be redefined using biology-informed frameworks integrating biological, behavioral, and environmental data. The Precision Psychiatry Roadmap aims to harmonize global research and clinical efforts to improve diagnostics and develop mechanism-based treatments.

Clinical Updates Wellness & Lifestyle

Decoding Fractional Exhaled Nitric Oxide (FeNO) Across the Lifespan: Establishing Normal Ranges in a Respiratory Healthy Population

By MedXY 08/30/2025

This study establishes reliable FeNO reference values throughout life in respiratory healthy individuals, highlighting factors that influence nitric oxide levels and enhancing asthma diagnosis and management.

Clinical Updates Wellness & Lifestyle

Unraveling Molecular Links Between Chronic Kidney Disease and Heart Failure via the Plasma Proteome

By MedXY 08/17/2025

A comprehensive proteomic analysis from the ARIC study identifies plasma proteins linking kidney dysfunction to incident heart failure, highlighting potential biomarkers and therapeutic targets for HF prevention in CKD patients.

Clinical Updates Wellness & Lifestyle

Vutrisiran’s Impact on Cardiac Function and Outcomes in Transthyretin Amyloid Cardiomyopathy: Insights from HELIOS-B

By MedXY 08/17/2025

Vutrisiran improves cardiac structure, function, and biomarkers, reducing mortality and cardiovascular events in transthyretin amyloid cardiomyopathy over 30 months.

Clinical Updates Wellness & Lifestyle

Predicting Long-Term Mortality: Insights from a Multi-Metabolite Signature in the PREDIMED Trial

By MedXY 08/11/2025

A study identified a robust plasma multi-metabolite signature that predicts long-term all-cause mortality in participants from the PREDIMED trial and several US cohorts, providing new insights into metabolic biomarkers.

Clinical Updates Wellness & Lifestyle

Dual Biomarker Strategy: Enhancing Prognosis in Acute Heart Failure with CA125 and NT-proBNP in Vietnam

By MedXY 08/08/2025

Combining CA125 with NT-proBNP significantly improves prediction of cardiovascular and all-cause mortality, as well as rehospitalization risk in patients with acute heart failure.

Clinical Updates

Type 2 Inflammation Biomarkers and Dupilumab Response in COPD: Insights from the BOREAS Phase 3 Trial

By MedXY 08/02/2025

Dupilumab significantly reduced type 2 inflammation biomarkers and exacerbation risk in COPD patients with elevated eosinophils, highlighting the value of biomarker-driven therapy.

Clinical Updates Wellness & Lifestyle

Functional MRI Brain Activation as a Predictor of Response to TNF Inhibition in Rheumatoid Arthritis: Insights from the PreCePra Phase 3 Study

By MedXY 08/02/2025

A phase 3 trial indicates that fMRI-detected CNS pain activation may predict which rheumatoid arthritis patients respond best to TNF inhibitor therapy.

Clinical Updates Medical News Neurology Specialties

Alzheimer’s Association Releases First Clinical Guidelines for Blood-Based Biomarkers: Implications for Diagnosis and Practice

By MedXY 07/29/2025

New Alzheimer’s Association guidelines endorse blood-based biomarkers as diagnostic adjuncts, not standalone tests, emphasizing rigorous clinical evaluation and high test accuracy.