Alzheimer’s disease

Unlocking the Predictive Power of Plasma Biomarkers for Early Alzheimer’s Disease Detection

By MedXY 10/27/2025

This review evaluates recent evidence on plasma AD biomarkers, especially phosphorylated tau217 and amyloid PET, for predicting cognitive decline in unimpaired individuals, highlighting their potential and limitations.

Neurology Specialties

Oral Valiltramiprosate in APOEε4/ε4 Carriers with Early Alzheimer’s Disease: Insights from the Phase III APOLLOE4 Trial

By MedXY 10/21/2025

This phase III trial evaluated oral valiltramiprosate in APOEε4/ε4 homozygotes with early Alzheimer's, showing brain atrophy slowing but limited overall clinical benefit, with nominal improvements in mild cognitive impairment subgroups.

Neurology news

Molecular Interplay of TREM2 and ApoE Variants in Alzheimer’s Disease: Structural Insights and Therapeutic Implications

By MedXY 10/21/2025

This article elucidates how TREM2-apoE3 interactions are structurally altered by Alzheimer's-associated TREM2 R47H and apoE4 variants, revealing potential mechanisms that contribute to disease risk and informing therapeutic targeting strategies.

Cardiology Neurology news Specialties

Obicetrapib’s Role in Modulating Alzheimer’s Disease Biomarkers in Patients with Cardiovascular Disease: A Landmark Clinical Study

By MedXY 10/21/2025

Obicetrapib, a CETP inhibitor, lowers Alzheimer’s biomarkers like p-tau217 in ASCVD patients, especially ApoE4 carriers, suggesting a potential preventive strategy for high-risk individuals.

Neurology news

Pregnancy Hypertension and Elevated p-tau217: A Midlife Indicator of Alzheimer’s Disease Risk in Women

By MedXY 10/21/2025

Pregnancy hypertension is independently associated with higher serum p-tau217 levels in midlife women, suggesting a link to preclinical Alzheimer’s disease pathology and potential for early screening and intervention.

Neurology Public Health Specialties

Comparative Performance of Dementia Risk Indices in the HUNT Study: Insights into CogDrisk, LIBRA, CAIDE, and More

By MedXY 10/21/2025

This study compares five dementia risk indices using data from the HUNT study, revealing CogDrisk as the most accurate predictor, though none outperformed a demographics-only model including age and education.

Neurology news Specialties

Rapamycin for Alzheimer’s Prevention in APOE4 Carriers: Restoring Brain Metabolism and Vascular Health

By MedXY 10/21/2025

Rapamycin shows promise in preventing Alzheimer's disease in APOE4 carriers by improving brain mitochondrial function, synaptic activity, and vascular health, highlighting a potential genotype-targeted early intervention for this high-risk population.

Family Medicine & Nutrition Neurology news Specialties

Lifetime Walking Intensity and Duration Reduce Amyloid-β Accumulation in Alzheimer’s Disease: Insights from a Korean Longitudinal Cohort

By MedXY 10/20/2025

A 4-year longitudinal study reveals that long-duration, high-intensity lifetime walking is associated with reduced amyloid-β accumulation in older adults, suggesting a neuroprotective effect when initiated early in life.

Neurology news Pathology & Lab Medicine Public Health

Moderate-to-Vigorous Physical Activity, p-tau181, and Cognition in Older Adults with Memory Complaints: Insights from the MAPT Study

By MedXY 10/20/2025

Higher moderate-to-vigorous physical activity slows p-tau181 increase, a marker of Alzheimer’s pathology, but elevated p-tau181 diminishes exercise-related cognitive benefits in older adults.

Internal Medicine Neurology news

Blood Biomarkers of Alzheimer’s Disease Predict Long-Term Muscle Strength Decline in Older Adults

By MedXY 10/20/2025

This study links Alzheimer’s disease-related blood biomarkers with accelerated muscle strength loss over 12 years, highlighting the interplay between neurodegeneration and physical decline in aging populations.

Neurology news

Advances in Alzheimer’s Diagnosis: A Comprehensive Review of CSF and Blood Biomarkers

By MedXY 10/20/2025

This article reviews a systematic meta-analysis of 15 cerebrospinal fluid and blood biomarkers for Alzheimer's disease, highlighting robust diagnostic performance of core markers T-tau, P-tau, and Aβ42 in clinical practice and research.

Nephrology Neurology news

Assessing the Role of Kidney Function in Alzheimer’s Disease Blood Biomarker Interpretation and Amyloid-β Positivity Prediction

By MedXY 10/20/2025

Kidney function influences certain Alzheimer's disease blood biomarker levels but, within normal to mild impairment ranges, does not improve prediction of amyloid-β positivity, supporting the clinical utility of blood biomarkers in AD diagnosis regardless of renal status.

Neurology news Psychiatry

Brexpiprazole in Alzheimer’s Disease-Related Agitation: Modest Gains Amidst Safety Uncertainties

By MedXY 10/12/2025

This review evaluates brexpiprazole's efficacy and safety for agitation in Alzheimer's disease, revealing modest symptom improvement but uncertain safety profiles, underscoring the need for individualized therapy and further research.

Neurology news Public Health

Alzheimer’s Disease: Navigating Controversies and Shaping Future Strategies

By MedXY 10/10/2025

Recent advances in anti-β amyloid monoclonal antibodies offer promising reductions in Alzheimer’s disease progression but spark debate regarding their clinical impact, cost-effectiveness, and accessibility. Emerging biomarkers and preventive approaches herald a new era in personalized dementia care.

Clinical Updates Neurology news

Clinically Meaningful Changes in Cognitive and Functional Measures Early in Alzheimer’s Disease: Insights from Population-Based Cohorts

By MedXY 09/28/2025

This review synthesizes evidence on clinically meaningful within-patient changes in cognitive and functional assessments among individuals transitioning to mild cognitive impairment (MCI), highlighting implications for clinical trials and early intervention in Alzheimer's disease and related dementias (ADRD).

Clinical Updates Diabetes & Endocrinology Neurology news Specialties

Promising Links Between Diabetes Medications and Alzheimer’s Disease Risk Reduction

By MedXY 09/25/2025

Recent real-world data suggest GLP-1 receptor agonists and SGLT2 inhibitors may lower Alzheimer’s disease risk more effectively than DPP-4 inhibitors, highlighting the need for randomized trials to confirm potential neuroprotective benefits.

Family Medicine & Nutrition Neurology news Specialties

Anti-Inflammatory Diet and Alzheimer’s Disease Mortality: Insights from a National Cohort Study

By MedXY 09/07/2025

Higher adherence to an anti-inflammatory diet is linked to lower all-cause mortality and a trend toward reduced Alzheimer's disease mortality, particularly among men and non-Hispanic Whites, highlighting dietary modification as a potential strategy to mitigate neuroinflammation and AD risk.

Clinical Updates Family Medicine & Nutrition Neurology news Specialties

Genotype-Specific Metabolic Insights and Mediterranean Diet Impact on Dementia Risk and Cognitive Health

By MedXY 09/04/2025

This article explores how genetic variants, plasma metabolites, and Mediterranean diet adherence interplay in modulating dementia risk and cognitive function, highlighting precision nutrition approaches for Alzheimer’s disease prevention.

Family Medicine & Nutrition Medical News Neurology news Specialties

Precision Nutrition: Can the Mediterranean Diet Reduce Alzheimer’s Risk in APOE4 Carriers?

By MedXY 09/04/2025

A large prospective study reveals that adherence to a Mediterranean diet significantly lowers dementia risk, especially in individuals carrying two copies of the APOE4 gene associated with Alzheimer’s disease, highlighting the potential of genetics-informed dietary strategies.

Clinical Updates Neurology news Specialties

Unraveling the Gut–Brain Connection: Tau Propagation via the Vagus Nerve in Alzheimer’s Disease

By MedXY 09/04/2025

Recent research reveals that pathological tau can propagate from the brain to the colon through the vagal efferent pathway in Alzheimer's disease, supporting a novel brain-to-gut axis involvement in disease progression and gut function impairment.