How Much Aerobic Exercise Is Enough to Reduce Depression in Patients with Chronic Illness? A Dose–Response Meta-analysis Points to an Achievable Target
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How Much Aerobic Exercise Is Enough to Reduce Depression in Patients with Chronic Illness? A Dose–Response Meta-analysis Points to an Achievable Target

A meta-analysis of 36 RCTs (n=2,500) found aerobic exercise significantly reduces depressive symptoms in people with chronic illness (Hedges' g -0.73). A weekly dose of ≈405 MET‑min (≈120–135 min of moderate aerobic activity) reaches a minimally important symptom change.
Synergistic Effects of Combined Aerobic and Resistance Exercise with Diet on Insulin Secretion and Neurotrophic Factors in Older Adults with Obesity
Posted inClinical Updates Diabetes & Endocrinology Family Medicine & Nutrition news Specialties

Synergistic Effects of Combined Aerobic and Resistance Exercise with Diet on Insulin Secretion and Neurotrophic Factors in Older Adults with Obesity

Combining aerobic and resistance exercise with diet-induced weight loss in older adults with obesity significantly improves insulin secretion, metabolic health, and physical function, likely mediated by ciliary neurotrophic factor receptor preservation and increased IGF-1 levels.