40 Hz – Medxy AI

40‑Hz Light During Sleep Evokes Gamma Activity Without Disrupting Sleep: A Feasibility Step Toward Noninvasive Dementia Therapies

By MedXY 11/09/2025

A proof‑of‑concept polysomnography study in 30 healthy adults shows that 40‑Hz visual stimulation during wakefulness, NREM2/3 and REM sleep reliably evokes gamma-band EEG responses without measurable sleep disruption, supporting feasibility for further therapeutic trials in dementia.

Neurology news Psychiatry

Gamma (40 Hz) Sensory Flicker Shows Promise for Insomnia but Needs Controlled Trials

By MedXY 11/09/2025

A prospective observational study of 37 adults with insomnia reports high adherence and no serious adverse events with 40 Hz light–sound flicker and sleep-diary improvements in sleep onset, arousals, and total sleep time; limitations include lack of control, objective measures, and small sample.

Neurology news

Two-Year 40 Hz Audiovisual Stimulation in Mild Alzheimer’s: Safety, EEG Entrainment, and Early Biomarker Signals

By MedXY 11/09/2025

An open-label two-year extension in five patients with mild Alzheimer's disease found daily 1‑hour 40 Hz audiovisual stimulation to be safe, produced sustained EEG gamma entrainment in late‑onset cases, and was associated with smaller cognitive decline and reductions in plasma pTau217 in two participants, warranting controlled trials.