Distinguishing Low-Grade MRI Inflammation in Rheumatoid Arthritis: Insights from Healthy Controls and At-Risk Populations

Distinguishing Low-Grade MRI Inflammation in Rheumatoid Arthritis: Insights from Healthy Controls and At-Risk Populations

This cohort study reveals that low-grade MRI-detected inflammation in hand, wrist, and forefoot joints is common in healthy individuals and at-risk groups, underscoring challenges in distinguishing rheumatoid arthritis-specific inflammation and highlighting the need to avoid MRI overinterpretation.
Advancing Radiotherapy in High-Grade Glioma: Targeted Volume Reduction with Hypofractionated Simultaneous Boost IMRT

Advancing Radiotherapy in High-Grade Glioma: Targeted Volume Reduction with Hypofractionated Simultaneous Boost IMRT

A randomized trial demonstrates that modified target delineation integrating multimodal MRI and white matter tractography with moderately hypofractionated radiotherapy achieves comparable survival outcomes to standard IMRT while reducing irradiation volumes in high-grade glioma patients.
Comparative Efficacy of Induction-Concurrent Versus Concurrent-Adjuvant Chemoradiotherapy in High-Risk N2-N3 Nasopharyngeal Carcinoma: Insights from a Phase 3 Randomized Trial

Comparative Efficacy of Induction-Concurrent Versus Concurrent-Adjuvant Chemoradiotherapy in High-Risk N2-N3 Nasopharyngeal Carcinoma: Insights from a Phase 3 Randomized Trial

A phase 3 trial showed no significant difference in 3-year progression-free survival between induction-concurrent and concurrent-adjuvant chemoradiotherapy in treating high-risk N2-N3 nasopharyngeal carcinoma, with both regimens exhibiting manageable safety profiles.
Mupirocin Nasal Ointment Significantly Reduces Severe Acute Radiation Oral Mucositis in Nasopharyngeal Cancer Patients: Insights from a Phase 3 Trial

Mupirocin Nasal Ointment Significantly Reduces Severe Acute Radiation Oral Mucositis in Nasopharyngeal Cancer Patients: Insights from a Phase 3 Trial

A phase 3 trial demonstrates that mupirocin nasal ointment used for bacterial decolonization effectively lowers severe acute radiation oral mucositis rates, improves quality of life, and reduces Staphylococcus aureus colonization in nasopharyngeal cancer patients undergoing radiotherapy.