Large Phase 3 Trials Show No Cognitive Benefit with Iclepertin in Schizophrenia — What the CONNEX Programme Teaches Us About Treating CIAS
Posted innews Psychiatry

Large Phase 3 Trials Show No Cognitive Benefit with Iclepertin in Schizophrenia — What the CONNEX Programme Teaches Us About Treating CIAS

Three multinational phase 3 trials found no clinically meaningful cognitive benefit of the GlyT1 inhibitor iclepertin versus placebo in schizophrenia, though the drug was well tolerated. Results highlight methodological and biological challenges in developing treatments for cognitive impairment associated with schizophrenia.
Metformin Moderately Reduces Antipsychotic-Related Weight Gain in Youth with Bipolar Spectrum Disorders: Large Pragmatic 24‑Month Trial Supports Clinical Use
Posted innews Pediatrics Psychiatry

Metformin Moderately Reduces Antipsychotic-Related Weight Gain in Youth with Bipolar Spectrum Disorders: Large Pragmatic 24‑Month Trial Supports Clinical Use

A 1,565‑participant pragmatic randomized trial shows metformin added to lifestyle counseling produced modest but statistically significant reductions in BMI Z-score at 6 and 24 months in overweight/obese children and adolescents with bipolar spectrum disorders taking second‑generation antipsychotics.
Metformin Modestly Reduces Antipsychotic-Associated Weight Gain in Youth with Bipolar Spectrum Disorders — Large Pragmatic Trial Supports Consideration in Practice
Posted innews Pediatrics Psychiatry

Metformin Modestly Reduces Antipsychotic-Associated Weight Gain in Youth with Bipolar Spectrum Disorders — Large Pragmatic Trial Supports Consideration in Practice

A large, pragmatic randomized trial found that adjunctive metformin produced a modest but statistically significant reduction in BMI Z-score at 6 and 24 months among overweight and obese youth with bipolar spectrum disorders treated with second-generation antipsychotics.
Stopping Smoking Is Associated With Better Recovery From Other Substance Use Disorders: Longitudinal Evidence From a US National Cohort
Posted innews Psychiatry Public Health

Stopping Smoking Is Associated With Better Recovery From Other Substance Use Disorders: Longitudinal Evidence From a US National Cohort

A longitudinal, nationally representative cohort study found that within-person transition from current to former cigarette smoking was associated with a 30–43% higher odds of sustained recovery from other substance use disorders, supporting integration of smoking cessation into SUD care.
High‑Intensity Interval Training Fails to Rescue Hippocampal Integrity in Adults With Cannabis Use Disorder — but Exercise Is Feasible and May Reduce Craving
Posted inNeurology news Psychiatry Rehabilitation Medicine

High‑Intensity Interval Training Fails to Rescue Hippocampal Integrity in Adults With Cannabis Use Disorder — but Exercise Is Feasible and May Reduce Craving

A randomized trial in adults with moderate–severe cannabis use disorder found 12 weeks of supervised HIIT did not improve a composite MRI measure of hippocampal integrity versus strength/resistance training; exercise participation was feasible and may reduce cannabis craving.
Distinct and Shared Risk Profiles for Suicide Attempt Versus Suicide: Insights from Danish Registers and Genomic Data
Posted innews Psychiatry Public Health

Distinct and Shared Risk Profiles for Suicide Attempt Versus Suicide: Insights from Danish Registers and Genomic Data

A large Danish register and genetic study shows overlapping but distinct environmental and genetic risk factors for nonfatal suicide attempts and death by suicide, with chronic and functional health problems linked more to attempts and severe somatic illness and psychopathology-related genetics more to suicide.
Intimacy, Intranasal Oxytocin, and Faster Wound Healing: A Randomized Trial Linking Touch, Sex, and Neuroendocrine Recovery
Posted inDermatology news Psychiatry

Intimacy, Intranasal Oxytocin, and Faster Wound Healing: A Randomized Trial Linking Touch, Sex, and Neuroendocrine Recovery

A double‑blind RCT in 160 healthy adults found that intranasal oxytocin combined with structured positive interaction and daily physical intimacy (affectionate touch, sex) was associated with reduced cortisol and modestly faster dermatologic wound healing, with caveats on robustness and generalizability.
High Burden of ARFID Symptoms in Adults with Disorders of Gut–Brain Interaction: A Population-Based Study Signals Need for Routine Screening
Posted inGastroenterology news Psychiatry

High Burden of ARFID Symptoms in Adults with Disorders of Gut–Brain Interaction: A Population-Based Study Signals Need for Routine Screening

A 2023 population survey of 4,002 adults in the UK and US found that positive screens for avoidant/restrictive food intake disorder (ARFID) were common among people with disorders of gut–brain interaction (DGBI) and associated with greater health burden, underweight, poorer quality of life, and higher healthcare use.