Nirsevimab in Chile’s First National RSV Campaign: 76% Reduction in RSV Hospitalisations and 85% Fewer ICU Admissions in Infants
Posted inInfectious Diseases news Pediatrics Public Health Respiratory

Nirsevimab in Chile’s First National RSV Campaign: 76% Reduction in RSV Hospitalisations and 85% Fewer ICU Admissions in Infants

A nationwide retrospective study from Chile finds that a universal nirsevimab immunisation strategy in 2024 reduced RSV-related lower respiratory tract infection hospitalisations by 76% and ICU admissions by 85%, with an NNT of 35 to prevent one RSV LRTI admission.
Real-world data suggest nirsevimab reduces RSV test-positivity up to 12 months but not beyond — cautious interpretation required
Posted inInfectious Diseases news Pediatrics Respiratory

Real-world data suggest nirsevimab reduces RSV test-positivity up to 12 months but not beyond — cautious interpretation required

A multicentre retrospective TriNetX analysis found reduced odds of RSV test-positivity for infants receiving nirsevimab when last dose was within 6–11 months before testing; protection was strongest within 6 months and not evident beyond 12 months. Methodological limits temper causal inference.
Less Sitting, More Sleep and MVPA Linked to Better Glycaemic Stability in Children with Type 1 Diabetes: A 2‑Year Compositional Analysis
Posted inDiabetes & Endocrinology news Pediatrics

Less Sitting, More Sleep and MVPA Linked to Better Glycaemic Stability in Children with Type 1 Diabetes: A 2‑Year Compositional Analysis

A longitudinal compositional analysis of 83 children with type 1 diabetes found that reallocating daily time away from sedentary behaviour toward sleep or moderate‑to‑vigorous physical activity (MVPA) was associated with lower HbA1c and interstitial glucose over two years.
Congenital CMV in Australia: Reported Cases Are a Small Fraction of Estimated Burden — Implications for Screening, Treatment, and Public Health
Posted inInfectious Diseases news Pediatrics

Congenital CMV in Australia: Reported Cases Are a Small Fraction of Estimated Burden — Implications for Screening, Treatment, and Public Health

National APSU surveillance (1999–2024) found 479 definite congenital CMV cases and dramatic under-ascertainment versus expected prevalence; symptomatic infants increasingly receive antivirals. Expanded surveillance, newborn screening, and clear treatment pathways are needed.
Unilateral Pediatric Chronic Otitis Media with Effusion Impairs Binaural Hearing and Raises Tinnitus Risk: Evidence Challenging Conservative Management
Posted innews Otorhinolaryngology Pediatrics

Unilateral Pediatric Chronic Otitis Media with Effusion Impairs Binaural Hearing and Raises Tinnitus Risk: Evidence Challenging Conservative Management

A prospective cross-sectional study finds unilateral chronic otitis media with effusion (COME) in children is associated with poorer spatial release from masking and high tinnitus prevalence, suggesting potential central auditory consequences that may warrant reappraisal of conservative treatment recommendations.
Cochlear Implant Benefits in Children with Single‑Sided Deafness: Better in Quiet, Challenged in Noise — and Time Matters
Posted innews Otorhinolaryngology Pediatrics

Cochlear Implant Benefits in Children with Single‑Sided Deafness: Better in Quiet, Challenged in Noise — and Time Matters

In 185 children receiving unilateral cochlear implants, residual acoustic hearing favored the non-implanted ear in quiet (especially for SSD), but noise attenuated that advantage. Shorter auditory deprivation and longer CI experience reduced asymmetry and increased bilateral benefit, underscoring the value of early intervention.
Longitudinal Developmental Outcomes and Early Cochlear Implantation Benefits in Children with Prelingual Single-Sided Deafness: Evidence Synthesis and Clinical Recommendations
Posted inClinical Updates news Otorhinolaryngology Pediatrics

Longitudinal Developmental Outcomes and Early Cochlear Implantation Benefits in Children with Prelingual Single-Sided Deafness: Evidence Synthesis and Clinical Recommendations

Early cochlear implantation in children with prelingual single-sided deafness improves spatial hearing and cognitive outcomes, supporting neurodevelopment and mitigating risks of auditory deprivation and cortical reorganization.
Early Cochlear Implantation Shows Variable but Clinically Relevant Benefits in Children with Single-Sided Deafness: A Western Australian 10‑Year Series
Posted innews Otorhinolaryngology Pediatrics

Early Cochlear Implantation Shows Variable but Clinically Relevant Benefits in Children with Single-Sided Deafness: A Western Australian 10‑Year Series

A retrospective 10‑year series from Perth Children's Hospital reports heterogeneous long‑term outcomes after pediatric cochlear implantation for single‑sided deafness; earlier implantation (within 1 year) was associated with greater likelihood of benefit in speech‑in‑noise and localization.