Clinically Meaningful Changes in Cognitive and Functional Measures Early in Alzheimer’s Disease: Insights from Population-Based Cohorts

Clinically Meaningful Changes in Cognitive and Functional Measures Early in Alzheimer’s Disease: Insights from Population-Based Cohorts

This review synthesizes evidence on clinically meaningful within-patient changes in cognitive and functional assessments among individuals transitioning to mild cognitive impairment (MCI), highlighting implications for clinical trials and early intervention in Alzheimer's disease and related dementias (ADRD).
Sustained Benefits of Physiology-Guided Complete Revascularization in Elderly Myocardial Infarction Patients: Insights from the FIRE Trial Three-Year Follow-Up

Sustained Benefits of Physiology-Guided Complete Revascularization in Elderly Myocardial Infarction Patients: Insights from the FIRE Trial Three-Year Follow-Up

The FIRE randomized clinical trial demonstrates that physiology-guided complete revascularization in patients aged 75 and older with myocardial infarction and multivessel disease maintains significant reductions in death, MI, stroke, and heart failure hospitalizations over a three-year follow-up, outperforming culprit-only treatment.