Posted inFamily Medicine & Nutrition news
Plate for the Planet: How the “Planetary Health Diet” Can Extend Your Life
In a world grappling with dual crises—rising chronic disease rates and accelerating climate change—a team…
Enhancing Access to Mifepristone via Community Pharmacies: Evidence from Routine Prescription Regulation in British Columbia, Canada
This review synthesizes data on mifepristone availability at community pharmacies in BC, highlighting geographic coverage, dispensing gaps, and disparities influencing timely access to medication abortion.
Posted inClinical Updates Diabetes & Endocrinology Family Medicine & Nutrition news OB/GYN & Women's Health
Planetary Health Diet and Cardiometabolic Risk Reduction in Women with Gestational Diabetes: An Evidence-Based Review
This review synthesizes evidence linking adherence to the Planetary Health Diet with reduced risks of myocardial infarction, type 2 diabetes, and improved weight management in women post-gestational diabetes, highlighting BMI's mediating role.
Posted inCritical Care news Pediatrics
Epinephrine Timing and Dosing in Pediatric In‑Hospital Cardiac Arrest: Mixed Signals — improved ROSC but unclear survival benefit
Recent multicenter studies show earlier and more frequent epinephrine in pediatric in‑hospital cardiac arrest increases ROSC and shortens CPR, but does not consistently improve survival to discharge or favorable neurologic outcome. Evidence supports rapid epinephrine for hemodynamics and ROSC; survival effects remain uncertain.
Offering Multiple Appropriate Alternatives Increases Primary Care Physicians’ Adoption of Recommended Care: A Randomized Trial
A randomized trial of 402 US primary care physicians found that presenting two or more appropriate treatment alternatives (vs one) increased clinicians’ likelihood of changing from a status quo plan to an evidence‑based alternative, especially for opioid prescribing; adding options beyond two provided no further benefit.
Posted inCritical Care news Pediatrics
Pediatric In‑Hospital Cardiac Arrest: Why Adult Resuscitation Lessons Don’t Fully Translate — Airway, Epinephrine, and the Limits of Training
Recent multicenter studies show declining intra‑arrest intubation, no clear harm from intubation after time‑dependent matching, unclear benefit of epinephrine before defibrillation, and no survival gain from intensive point‑of‑care CPR training—highlighting pediatric physiology and knowledge gaps.
Posted inGastroenterology news Pediatrics
Condition-Specific Growth Charts and a New Medical Therapy for Alagille Syndrome: Implications for Growth Assessment and Symptom Control
Two recent multicenter studies provide condition-specific growth charts for children with Alagille syndrome and show that ileal bile acid transporter inhibition with odevixibat reduces pruritus and serum bile acids — reshaping growth assessment and medical management.
Posted inCritical Care Emergency Medicine Neurology news
Prehospital Postintubation Hypotension Strongly Linked to 30‑Day Mortality After Severe Traumatic Brain Injury — Especially in Isolated TBI
A multicenter cohort study of 555 patients with severe TBI who underwent prehospital rapid sequence induction found postintubation hypotension (SBP <90 mmHg within 10 minutes) in 19.1%, which was associated with higher 30‑day mortality (AOR 1.70). The association was markedly stronger in isolated TBI (AOR 13.55).
Posted inDiabetes & Endocrinology news Public Health
Early-Life Famine Exposure in Chinese Immigrants Strongly Linked to Later Diabetes and Hypertension — But Not Cardiovascular Hospitalization
A large Ontario cohort study links early-life exposure to the Great Chinese Famine with higher adult risks of type 2 diabetes and hypertension among Chinese immigrants, while cardiovascular hospitalization was not increased; methodological caveats underline need for age-balanced research.
Posted inClinical Updates Gastroenterology news Oncology
Proton Pump Inhibitor Use and Survival Outcomes in Newly Diagnosed Glioblastoma: An Evidence-Based Review
Proton pump inhibitor use, particularly potent ALDH1A1-activating PPIs, is associated with worse survival in newly diagnosed glioblastoma, highlighting the need for cautious use and further mechanistic research.
Posted inClinical Updates news Pediatrics Respiratory
Reevaluating the Link Between Household Air Pollution from Biomass Cooking and Severe Pneumonia in Infants: A Comprehensive Evidence Synthesis
Recent high-quality studies challenge the presumed association between household air pollution from biomass cooking and severe infant pneumonia, highlighting inconsistent exposure-response relationships for PM2.5 and CO.
Posted inCardiology news Psychiatry
Tailored Digital Emotion Regulation Improves Mental Health in Adults With Congenital Heart Disease: Results of a National Randomized Trial
A 3‑arm randomized trial in 524 adults with congenital heart disease found a 4‑week tailored digital emotion‑regulation program produced moderate improvements in emotion regulation and multiple psychosocial outcomes versus usual care; a general program showed delayed, smaller benefits.
Atezolizumab–Bevacizumab Provides the Best Balance of Survival and Quality of Life in First‑Line Advanced Hepatocellular Carcinoma
A Bayesian network meta-analysis integrating health‑related quality of life and overall survival across first‑line trials in advanced hepatocellular carcinoma shows atezolizumab plus bevacizumab provides the most favorable combined patient‑centered outcome profile.
Posted innews Pediatrics
Supplemental Donor Human Milk Did Not Speed Full Enteral Feeding in Moderate–Late Preterm Infants: Results From a Multisite Randomized Trial
In a blinded multisite RCT of 201 moderate–late preterm infants, short-term supplementation with pasteurized donor human milk versus term formula did not shorten time to full enteral feeds; donor milk was associated with slower regain of birth weight.
Posted inAI news Rheumatology
Digital Psychological Intervention Reduces Distress and Improves Quality of Life in Inflammatory Rheumatic Diseases: Results from a Pilot RCT
A 102-participant pilot RCT in Germany found that a self-guided digital psychological intervention produced clinically meaningful reductions in psychological distress and modest improvements in quality of life at 3 months in people with inflammatory rheumatic diseases.
Posted inCritical Care news Rehabilitation Medicine
Early Neuromuscular Electrical Stimulation Plus Mobilization Improves 6‑Month Function and Quality of Life After Critical Illness
In a randomized, blinded trial of 74 mechanically ventilated ICU patients, adding early NMES to an early mobilization program started within 48 hours improved functional status, independence, mobility, and quality of life up to 6 months after discharge versus mobilization alone.
Posted inCritical Care news
Bridging the Gap: Improving Agreement Between Nurse-Documented ICDSC and Researcher CAM-ICU Delirium Assessments in the ICU
A predictive model combining bedside nurse ICDSC items and clinical variables (ventilation, SOFA) substantially improves agreement with researcher CAM-ICU assessments, enabling more accurate, scalable delirium ascertainment in ICU research and quality efforts.
Posted inClinical Updates news Respiratory Transplantation
Development and Validation of an Interpretable Hybrid Machine Learning Model for Predicting Long-term Lung Transplant Outcomes
This review synthesizes evidence on a novel hybrid machine learning model leveraging US lung transplant registry data to predict mortality or retransplant risk at 1, 5, and 10 years, highlighting its clinical utility and balanced interpretability.
Posted inNeurology news Pathology & Lab Medicine Radiology
Stage-specific Tau-PET Dynamics in Biological Alzheimer’s Disease: Implications for Trial Design and Outcome Selection
Longitudinal tau-PET accumulation follows distinct regional patterns across biological AD stages; aligning trial inclusion and outcome ROIs to baseline tau stage can substantially reduce sample sizes and improve power for disease-modifying trials.
Posted inCritical Care Infectious Diseases news
ICU Structure and Care Processes Drive VAP and CLABSI Burden in Brazilian ICUs: Insights from the IMPACTO‑MR Nested Cohort
A large multicenter Brazilian cohort found that ICU-level structure and process measures — staffing, prevention protocols, hand hygiene training, visitation policies, and specific clinical roles — explain substantial between-hospital variability and are associated with lower VAP and CLABSI rates.