Specialties – Page 46

Dual αvβ6 and αvβ1 Integrin Inhibition Reduces Lung Collagen Deposition in Idiopathic Pulmonary Fibrosis: Insights from a Phase 2 Clinical Trial

By MedXY 10/28/2025

This phase 2 trial demonstrates that bexotegrast, a dual αvβ6/αvβ1 integrin inhibitor, significantly reduces active type I collagen deposition in IPF lungs, indicating antifibrotic potential and favorable lung remodeling over 12 weeks.

Gastroenterology Internal Medicine news

Bexotegrast in Primary Sclerosing Cholangitis: Promising Safety and Pharmacodynamics from Phase II INTEGRIS-PSC Trial

By MedXY 10/28/2025

The Phase II INTEGRIS-PSC trial demonstrates that bexotegrast, a dual αvβ6/αvβ1 integrin inhibitor, is well tolerated in PSC patients with liver fibrosis and shows potential to attenuate fibrotic progression, supporting integrin-targeted therapy as a novel approach.

news Oncology

Lenvatinib as a Promising Second-Line Therapy for Advanced Hepatocellular Carcinoma Post-Atezolizumab Plus Bevacizumab Failure: Insights from a Multicenter Phase II Trial

By MedXY 10/28/2025

A recent phase II trial demonstrates lenvatinib's efficacy and manageable safety as a second-line treatment for unresectable hepatocellular carcinoma after progression on first-line atezolizumab plus bevacizumab.

Critical Care Gastroenterology news

Innovative Extracorporeal Therapy Combining HLA-Depleted Liver Organoids and Granulocyte-Monocyte Apheresis for Reversal of Acute Liver Failure

By MedXY 10/28/2025

The UTOpiA system, integrating HLA-depleted iPSC-derived liver organoids with granulocyte-monocyte apheresis, significantly improves survival and liver regeneration in acute-on-chronic and acute liver failure rat models, representing a promising off-the-shelf extracorporeal liver support therapy.

Gastroenterology Internal Medicine news

Long-Term Real-World Effectiveness, Safety, and Liver Stiffness Changes with Obeticholic Acid in Primary Biliary Cholangitis

By MedXY 10/28/2025

This study confirms the sustained effectiveness and safety of obeticholic acid (OCA) in primary biliary cholangitis (PBC) over a 2-year median follow-up, highlighting its impact on liver stiffness and fibrosis progression, especially in biochemical responders.

Gastroenterology news Pathology & Lab Medicine

Liver Stiffness Measurement vs. Biochemical Response in Primary Biliary Cholangitis: Predicting Liver Decompensation with Precision

By MedXY 10/28/2025

In primary biliary cholangitis, liver stiffness measurement (LSM) outperforms biochemical response in predicting first hepatic decompensation, emphasizing LSM's pivotal role in clinical risk stratification despite frequent discordances between these parameters.

Gastroenterology news Pathology & Lab Medicine

Standardizing Liver Biopsy Interpretation in MASH Trials: Key Consensus Statements from the International MASLD Pathology Group

By MedXY 10/28/2025

An evidence-based, practical summary of the IMPG consensus on standardized histologic grading and staging for MASH (MASLD) clinical trials, with recommendations for biopsy processing, feature definitions, scoring, central reading, and AI-ready datasets.

Nephrology news Transplantation

IXA Position Paper: Practical Roadmap for First-in-Human Porcine Kidney Xenotransplantation

By MedXY 10/28/2025

The International Xenotransplantation Association (IXA) 2025 position paper offers evidence-based recommendations for initial clinical trials of genetically engineered porcine kidney transplants for end-stage renal disease, focusing on donor genetics, immunosuppression, patient selection, infection monitoring and ethical/regulatory safeguards.

Gastroenterology General Surgery news

Breaking New Ground: The First Genetically Engineered Pig-to-Human Liver Xenotransplantation

By MedXY 10/28/2025

This landmark study reports the first successful genetically engineered pig auxiliary liver transplanted into a living human, revealing critical insights on immunological compatibility and post-transplant complications, advancing liver xenotransplantation toward clinical application.

news Oncology

Alcohol’s Amplifying Effect on HBV-Related Liver Cancer: New Insights into Metabolic Reprogramming

By MedXY 10/27/2025

This article explores how alcohol consumption worsens HBV-induced hepatocellular carcinoma by promoting ER stress and lipid metabolic disturbances, highlighting potential therapeutic targets like LPLA2 and BMP.

Cardiology Gastroenterology news

Early Portopulmonary Hypertension in Cirrhosis: A Prognostic Marker of Increased Mortality

By MedXY 10/27/2025

Early-stage portopulmonary hypertension, defined by revised 2022 ESC/ERS criteria, independently predicts mortality in patients with cirrhosis, underscoring the importance of systematic screening and early intervention.

Infectious Diseases Internal Medicine news

Targeting HBx-Induced HSPB1: A Novel Approach to Combat Chronic Hepatitis B and Boost Liver Immunity

By MedXY 10/27/2025

This review explores the potential of targeting HBx-induced HSPB1 to suppress HBV cccDNA and enhance hepatic immune responses, highlighting a promising peptide-based therapeutic approach.

Internal Medicine Neurology news

Emerging Role of GLP-1 and GIP/GLP-1 Receptor Agonists in Managing Idiopathic Intracranial Hypertension

By MedXY 10/27/2025

This review analyzes current evidence supporting the use of GLP-1 and GIP/GLP-1 receptor agonists in IIH, highlighting benefits in reducing papilledema, visual disturbances, and headaches.

Clinical Updates Neurology news

GLP-1 Receptor Agonists in Idiopathic Intracranial Hypertension: Emerging Evidence and Clinical Implications

By MedXY 10/27/2025

GLP-1 receptor agonists show promise in idiopathic intracranial hypertension by reducing symptoms, medication use, surgical interventions, and mortality, independent of significant BMI change, highlighting a novel therapeutic approach warranting further prospective evaluation.

Allergy & Immunology news Pediatrics Respiratory

Unveiling Diverse Inflammatory Pathways in Residual Pediatric Asthma Exacerbations Under Mepolizumab Therapy

By MedXY 10/27/2025

This study reveals multiple distinct molecular mechanisms, including epithelial and macrophage pathways, that contribute to residual asthma exacerbations in children treated with mepolizumab, highlighting the complexity of airway inflammation.

news Oncology Urology

Rethinking Gleason Grade Group 1 Prostate Cancer: Insights from a Large-Scale Cohort Study

By MedXY 10/27/2025

This study highlights the heterogeneity of GG1 prostate cancer and its implications for classification and management strategies.

news Psychiatry

Evaluating Antidepressant Impact on Bipolar Depression: Insights from a Propensity Score Analysis in the STEP-BD Cohort

By MedXY 10/27/2025

A propensity score analysis of STEP-BD data reveals no significant association between antidepressant use and either manic switch risk or symptomatic remission in bipolar depression, highlighting the need for alternative treatment strategies.

Neurology news Psychiatry

Unlocking the Predictive Power of Plasma Biomarkers for Early Alzheimer’s Disease Detection

By MedXY 10/27/2025

This review evaluates recent evidence on plasma AD biomarkers, especially phosphorylated tau217 and amyloid PET, for predicting cognitive decline in unimpaired individuals, highlighting their potential and limitations.

Emergency Medicine Hematology-Oncology news Pediatrics

Timely Opioid Administration in Pediatric Emergency Departments Reduces Hospitalizations for Acute Sickle Cell Pain

By MedXY 10/27/2025

Prompt opioid delivery in pediatric EDs for sickle cell pain significantly lowers hospitalization rates, with the greatest benefit seen when the first dose is given within 60 minutes and the second dose within 30 minutes.

Clinical Updates news Psychiatry

Functional Connectivity as a Predictor of Transdiagnostic Treatment Outcomes in Internalizing Psychopathologies: Advances and Clinical Implications

By MedXY 10/27/2025

Whole-brain functional connectivity patterns predict multidimensional treatment outcomes across internalizing psychopathologies and various therapies, highlighting neural network biomarkers for personalized psychiatric care.