Updated Basal Calcitonin Cutoffs Better Predict Extent of Lymph Node Metastasis in Medullary Thyroid Cancer
Posted inDiabetes & Endocrinology news Otorhinolaryngology

Updated Basal Calcitonin Cutoffs Better Predict Extent of Lymph Node Metastasis in Medullary Thyroid Cancer

A multicenter Chinese cohort identifies new preoperative basal calcitonin thresholds (241.9, 693.9, 2378.5, 2787.1 pg/mL) that stratify risk of central, ipsilateral lateral, bilateral/contralateral lateral, and upper mediastinal lymph node metastasis and improve prediction of structural recurrence-free survival versus ATA guidance.
Proton Beam vs IMRT for Olfactory Neuroblastoma: Multicenter Propensity-Matched Cohort Shows No Clear Superiority
Posted innews Oncology Otorhinolaryngology

Proton Beam vs IMRT for Olfactory Neuroblastoma: Multicenter Propensity-Matched Cohort Shows No Clear Superiority

A multicenter propensity-matched cohort comparing adjuvant proton beam radiotherapy (PBRT) with intensity-modulated radiotherapy (IMRT) for olfactory neuroblastoma found no definitive differences in local control, recurrence-free survival, overall survival, or clinically meaningful reductions in grade ≥2 radiation toxicities, but estimates were imprecise.
Radiotherapy for Growing Vestibular Schwannomas: Real‑World Tumor Control and What It Means for Practice
Posted innews Oncology Otorhinolaryngology

Radiotherapy for Growing Vestibular Schwannomas: Real‑World Tumor Control and What It Means for Practice

An international multicenter cohort of 1,883 patients with radiologically growing vestibular schwannomas treated first‑line with radiotherapy showed a 10‑year tumor control rate of 76.1% (primary definition). Control estimates varied widely by growth definition, underscoring the clinical importance of outcome metrics.
Adenotonsillectomy vs Watchful Waiting in Young Children with Mild–Moderate OSA: Long-term Findings from the KATE Randomized Trial
Posted innews Otorhinolaryngology Pediatrics

Adenotonsillectomy vs Watchful Waiting in Young Children with Mild–Moderate OSA: Long-term Findings from the KATE Randomized Trial

The KATE trial (n=60) found no between-group difference in polysomnographic OAHI change after 3 years, though adenotonsillectomy improved disease-specific quality of life. Nearly 42% of watchful-waiting children later underwent surgery, suggesting watchful waiting is reasonable for selected young children with mild OSA and small tonsils but requires close follow-up.
Neural Networks Predict Survival for Older Adults With Head and Neck Cancer — Useful, but Not Yet Practice-Changing
Posted innews Oncology Otorhinolaryngology

Neural Networks Predict Survival for Older Adults With Head and Neck Cancer — Useful, but Not Yet Practice-Changing

An international cohort study developed and externally validated artificial neural networks that stratify older adults with locoregionally advanced head and neck squamous cell carcinoma (HNSCC) treated with definitive chemoradiation. Models showed moderate discrimination (OS AUC 0.68, PFS AUC 0.64) with HPV status, kidney function, ECOG, and nodal stage among top predictors.
APOE ε4, Age and Sex Converge to Disturb Anterior Olfactory Nucleus Physiology: Electrophysiologic Evidence for Early Alzheimer’s Vulnerability
Posted inNeurology news Otorhinolaryngology

APOE ε4, Age and Sex Converge to Disturb Anterior Olfactory Nucleus Physiology: Electrophysiologic Evidence for Early Alzheimer’s Vulnerability

In vivo awake recordings in transgenic mice show APOE ε4 reduces neuronal excitability in the anterior olfactory nucleus (AON); adult females are more excitable than males (a sex difference lost with aging), while aging amplifies network oscillatory power — revealing interactions that may underlie early olfactory deficits in Alzheimer’s disease.