Icosabutate and FFAR1/FFAR4 Agonism in Metabolic Dysfunction-Associated Steatohepatitis (MASH): Insights from the ICONA Phase IIb Trial
Posted inClinical Updates Gastroenterology Internal Medicine news Specialties

Icosabutate and FFAR1/FFAR4 Agonism in Metabolic Dysfunction-Associated Steatohepatitis (MASH): Insights from the ICONA Phase IIb Trial

The phase IIb ICONA trial evaluated icosabutate, a dual FFAR1/FFAR4 agonist, in patients with MASH, showing fibrosis improvement without meeting the primary endpoint, and supporting further development particularly in advanced fibrosis and diabetic populations.
High-Dose vs Standard-Dose Influenza Vaccine in Older Adults: Insights from the DANFLU-2 Randomized Clinical Trial
Posted inClinical Updates Internal Medicine news Public Health Respiratory Specialties

High-Dose vs Standard-Dose Influenza Vaccine in Older Adults: Insights from the DANFLU-2 Randomized Clinical Trial

The DANFLU-2 trial demonstrates that high-dose influenza vaccine reduces cardiovascular and cardiorespiratory hospitalizations compared to standard-dose in adults ≥65 years, with similar benefits across subgroups including heart failure and atherosclerotic cardiovascular disease.
Synergistic Impact of Probiotic and Omega-3 Supplementation Combined with Ultra-Short Race Pace Training on Sprint Swimming Performance
Posted inClinical Updates Family Medicine & Nutrition Internal Medicine news Specialties

Synergistic Impact of Probiotic and Omega-3 Supplementation Combined with Ultra-Short Race Pace Training on Sprint Swimming Performance

Combining probiotics and omega-3 supplementation with ultra-short race pace training significantly enhances sprint swimming performance by improving anaerobic capacity, neuromuscular function, and body composition in competitive male swimmers.