Dose-Dependent Enhancement of L-Tryptophan-Induced Gut Hormone Secretion and Appetite Suppression by Intraduodenal Calcium in Obesity
Posted inClinical Updates Family Medicine & Nutrition Gastroenterology news Specialties

Dose-Dependent Enhancement of L-Tryptophan-Induced Gut Hormone Secretion and Appetite Suppression by Intraduodenal Calcium in Obesity

Intraduodenal calcium at doses up to 1000 mg amplifies the anorexigenic effects of L-tryptophan by boosting gut hormones CCK, GLP-1, and PYY, reducing energy intake in obese males, highlighting a novel adjunctive approach for appetite regulation in obesity management.
Optimizing Colorectal Cancer Screening Outreach for Adults Aged 45-49: Insights From a Large-Scale Randomized Trial
Posted inClinical Updates Gastroenterology Oncology Public Health Specialties

Optimizing Colorectal Cancer Screening Outreach for Adults Aged 45-49: Insights From a Large-Scale Randomized Trial

A large UCLA Health randomized clinical trial found that usual care via mailed FIT outreach outperformed active choice strategies in colorectal cancer screening uptake among adults aged 45 to 49 years, highlighting the challenges in engaging younger populations in screening programs.
Parecoxib and Imrecoxib Sequential Therapy: A Breakthrough in Managing Severe Acute Pancreatitis
Posted inClinical Updates Critical Care Emergency Medicine Gastroenterology news Specialties

Parecoxib and Imrecoxib Sequential Therapy: A Breakthrough in Managing Severe Acute Pancreatitis

This multicentre trial shows sequential use of COX-2 inhibitors parecoxib and imrecoxib significantly reduces severe acute pancreatitis (SAP) incidence, shortens organ failure duration, lowers local complications, and decreases 30-day mortality, with a good safety profile.
Alopecia Areata Linked to Elevated Risk of Microscopic Colitis and Other Immune-Mediated GI Disorders: Clinical Insights
Posted inAllergy & Immunology Clinical Updates Dermatology Gastroenterology

Alopecia Areata Linked to Elevated Risk of Microscopic Colitis and Other Immune-Mediated GI Disorders: Clinical Insights

A large retrospective cohort study identifies a significant association between alopecia areata and increased risks of microscopic colitis, celiac disease, Crohn’s disease, eosinophilic esophagitis, and ulcerative colitis, highlighting the need for gastrointestinal screening in affected patients.
Unraveling Chronic Stress: The Role of Gut Dysbiosis and Vitamin B6 Metabolism in Stress-Related Brain Disorders Independent of Cortisol
Posted inFamily Medicine & Nutrition Gastroenterology Psychiatry Public Health Specialties

Unraveling Chronic Stress: The Role of Gut Dysbiosis and Vitamin B6 Metabolism in Stress-Related Brain Disorders Independent of Cortisol

Recent evidence reveals gut dysbiosis-induced vitamin B6 metabolic disturbances as a novel, cortisol-independent mechanism driving chronic stress-related abnormal behaviors and inflammation, highlighting probiotic and vitamin B6 supplementation as potential therapeutic strategies.