Cardiology – Page 18

Genetic Tug-of-War: How Polygenic Background Dictates the Penetrance and Phenotype of Monogenic Cardiomyopathies

By MedXY 12/23/2025

A large-scale study from the Penn Medicine BioBank demonstrates that polygenic risk scores for hypertrophic and dilated cardiomyopathies act as bidirectional modifiers, influencing the clinical expression of rare pathogenic variants and offering a new paradigm for cardiovascular risk stratification.

Anesthesiology Cardiology news

Preoperative Cardiovascular Risk Does Not Dictate RAS Inhibitor Management: Insights from the STOP-or-NOT Trial

By MedXY 12/22/2025

A post hoc analysis of the STOP-or-NOT trial demonstrates that preoperative cardiovascular risk stratification does not influence the outcomes of continuing versus discontinuing renin-angiotensin system inhibitors before major noncardiac surgery, supporting a flexible approach to perioperative management.

Cardiology Clinical Updates Diabetes & Endocrinology news

Diabetes, Obesity, and Early Rhythm Control in Atrial Fibrillation: Insights from the EAST-AFNET 4 Trial

By MedXY 12/22/2025

This analysis of the EAST-AFNET 4 trial highlights that early rhythm control therapy's cardiovascular benefits and safety are consistent regardless of diabetes or obesity status in atrial fibrillation patients.

Cardiology news

Obstructive Coronary Artery Disease Does Not Diminish Long-Term Health Status or Clinical Efficacy After TAVR: 3-Year Insights from SCOPE I

By MedXY 12/21/2025

A post hoc analysis of the SCOPE I trial reveals that obstructive coronary artery disease (CAD) does not significantly impact 3-year survival or patient-reported health status following TAVR, questioning the routine necessity of periprocedural PCI in this population.

Cardiology Diabetes & Endocrinology news

Heart Failure Mortality: The Resilient Challenge in an Era of Declining Cardiovascular Deaths

By MedXY 12/20/2025

This multi-national analysis of 2.92 million deaths highlights a concerning trend: while coronary and stroke mortality have plummeted, heart failure mortality remains stagnant or rising, with people with diabetes bearing a disproportionate and unchanging excess risk over the last two decades.

Cardiology Clinical Updates news

Ticagrelor Plus Aspirin Versus Aspirin Alone After Coronary Artery Bypass Grafting in Acute Coronary Syndrome: A Contemporary Evidence Synthesis

By MedXY 12/18/2025

This review synthesizes current evidence on the efficacy and safety of ticagrelor combined with aspirin compared to aspirin alone following CABG for acute coronary syndrome, highlighting the 2025 TACSI trial and its implications for clinical practice.

Cardiology Diabetes & Endocrinology news

Tirzepatide Achieves Cardiovascular Noninferiority Against Dulaglutide: A Milestone in Dual Incretin Therapy

By MedXY 12/18/2025

The SURPASS-CVOT trial confirms that tirzepatide is noninferior to dulaglutide for cardiovascular safety in high-risk type 2 diabetes patients. While superiority was not statistically reached, the study solidifies the cardiovascular profile of dual GIP/GLP-1 agonism compared to established standards of care.

Cardiology Infectious Diseases news

Prophylactic Strategies to Prevent Infection in Lower Limb Peripheral Arterial Reconstruction: Evidence and Clinical Implications

By MedXY 12/17/2025

Cochrane review shows prophylactic antibiotics may reduce SSI risk in peripheral arterial reconstruction; closed incision negative pressure therapy offers possible benefit but evidence is low.

Cardiology Neurology news

Combined Cardiorespiratory and Resistance Training After Stroke: Small Gains, Big Questions

By MedXY 12/17/2025

Evidence suggests combined aerobic and strength training post-stroke yields modest improvements in fitness and function but uncertain long-term benefits.

Cardiology news

Rare but High-Risk: New-Onset RBBB After TAVR Strongly Linked to Pacemaker Need

By MedXY 12/17/2025

New-onset right bundle branch block after TAVR is rare but carries a high risk of requiring permanent pacing within one week.

Cardiology news

Prophylactic Pacemakers After TAVR: Low Pacing Burden Raises Questions on Routine Use

By MedXY 12/17/2025

One-fourth of TAVR patients receive prophylactic pacemakers, but most have minimal pacing needs at 30 days.

Cardiology news

PROMOTE Study Validates Algorithm for Conduction Disturbance Management After TAVR

By MedXY 12/17/2025

A prospective multicenter study confirms that a prespecified algorithm for conduction disturbance management after TAVR is safe, with low sudden cardiac death risk but persistent high pacemaker rates.

Cardiology news

Distinct Mechanisms Drive Early and Delayed Heart Block After TAVR: Insights from Boston Cohort Study

By MedXY 12/17/2025

Prospective cohort study reveals AV nodal versus infranodal conduction patterns underpinning timing of heart block after TAVR.

Cardiology Internal Medicine news

Riboflavin and Blood Pressure: Evidence Remains Uncertain Despite Genetic Promise

By MedXY 12/16/2025

Cochrane review shows uncertain effects of riboflavin on blood pressure, highlighting a need for larger and better-quality trials.

Cardiology Neurology news

Low-Dose Colchicine Reduces Myocardial Infarction and Stroke Risk in Cardiovascular Disease Patients

By MedXY 12/16/2025

A large meta-analysis shows colchicine can lower MI and stroke risk without raising serious adverse events, but GI side effects remain a concern.

Cardiology news

Long-Term Hormone Therapy in Menopausal Women: Balancing Benefits and Risks

By MedXY 12/16/2025

Updated Cochrane review shows mixed outcomes for long-term hormone therapy in peri- and postmenopausal women.

Cardiology Neurology news

Beyond the Lesion: Long-Term Cardiovascular, Neurologic, Psychiatric, and Endocrine Risks After Traumatic Spinal Cord Injury

By MedXY 12/15/2025

A large retrospective cohort study shows traumatic spinal cord injury (TSCI) is associated with increased long-term cardiovascular, neurologic, psychiatric, and endocrine morbidity and higher mortality, even in previously healthy adults.

Cardiology news Psychiatry

Tailored Digital Emotion Regulation Improves Mental Health in Adults With Congenital Heart Disease: Results of a National Randomized Trial

By MedXY 12/14/2025

A 3‑arm randomized trial in 524 adults with congenital heart disease found a 4‑week tailored digital emotion‑regulation program produced moderate improvements in emotion regulation and multiple psychosocial outcomes versus usual care; a general program showed delayed, smaller benefits.

Cardiology Clinical Updates General Surgery news

Prothrombin Complex Concentrate versus Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery: Evidence Synthesis from the FARES-II Multicenter Randomized Clinical Trial and Related Studies

By MedXY 12/13/2025

This review synthesizes evidence demonstrating that 4-factor prothrombin complex concentrate (4F-PCC) offers superior hemostatic efficacy and safety compared to frozen plasma in managing coagulopathic bleeding during cardiac surgery, supported by the recent FARES-II trial and corroborating clinical research.

Cardiology news Pediatrics

Expectant Management Improves Early Survival Without Increasing BPD: Results from the PDA Randomized Clinical Trial

By MedXY 12/12/2025

In extremely preterm infants with a protocol-defined PDA, expectant management yielded similar rates of death or BPD at 36 weeks’ postmenstrual age but significantly higher survival compared with active pharmacologic closure.