Medxy AI

Efficacy and Safety of cAMP-Biased GLP-1 Receptor Agonist Ecnoglutide Versus Dulaglutide in Type 2 Diabetes: Insights from the EECOH-2 Phase 3 Trial and Broader Clinical Context

By MedXY 09/17/2025

Ecnoglutide, a novel cAMP-biased GLP-1 receptor agonist, demonstrated non-inferior glycemic control and comparable safety to dulaglutide at 52 weeks in type 2 diabetes patients on metformin, offering a promising new treatment option.

$Pitolisant as Adjunct Therapy for Refractory Restless Legs Syndrome: Insights from a Pilot Study$

Clinical Updates Wellness & Lifestyle

Pitolisant as Adjunct Therapy for Refractory Restless Legs Syndrome: Insights from a Pilot Study

By MedXY 09/17/2025

This pilot study reveals that adjunctive pitolisant, a histamine-3 inverse agonist, is well tolerated and improves symptom scales in refractory restless legs syndrome, suggesting potential to address daytime consequences with minimal core symptom relief. Controlled trials are warranted.

$Camlipixant for Refractory Chronic Cough: Promising Phase 2b Trial Results and Clinical Implications$

Clinical Updates Wellness & Lifestyle

Camlipixant for Refractory Chronic Cough: Promising Phase 2b Trial Results and Clinical Implications

By MedXY 09/17/2025

The SOOTHE phase 2b trial demonstrates that camlipixant, a P2X3 antagonist, significantly reduces cough frequency and improves quality of life in refractory chronic cough patients, with a favorable safety profile, supporting its potential as a new therapeutic option.

Clinical Updates Wellness & Lifestyle

Bexotegrast Shows Promise in Treating Idiopathic Pulmonary Fibrosis: Insights from the INTEGRIS-IPF Phase 2a Trial

By MedXY 09/17/2025

The INTEGRIS-IPF trial demonstrates that bexotegrast is well tolerated and may reduce lung function decline in IPF patients, offering hope for a novel antifibrotic therapy.

Clinical Updates Wellness & Lifestyle

Optimizing Pyrazinamide Dosing in Drug-Susceptible Pulmonary Tuberculosis: Insights from a Large Phase 3 Trial

By MedXY 09/17/2025

A comprehensive analysis from the TBTC Study 31/ACTG A5349 reveals that flat dosing of pyrazinamide at 1,000 mg daily optimizes efficacy and safety, challenging current weight-banded dosing strategies for drug-susceptible tuberculosis.

Clinical Updates Wellness & Lifestyle

Lung-Protective Mechanical Ventilation in Acute Brain Injury: Insights from the PROLABI Trial

By MedXY 09/17/2025

The PROLABI trial assessed lung-protective ventilation in acute brain injury patients and found no improvement in mortality, ventilator dependency, or ARDS incidence, highlighting the need for further research in this population.

Clinical Updates Wellness & Lifestyle

Optimizing Metabolic and Physical Health in Obese Older Adults: Impact of Exercise Modalities on Insulin Secretion, CNTF, and IGF-1 During Weight Loss

By MedXY 09/17/2025

Combining aerobic and resistance exercise with diet-induced weight loss in obese older adults significantly improves insulin secretion, preserves CNTFRα levels, and increases IGF-1, enhancing metabolic and physical function.

Clinical Updates Wellness & Lifestyle

Hydroxytyrosol Supplementation Enhances Antioxidant and Anti-Inflammatory Status in Overweight Prediabetic Adults: Insights from a Randomized Controlled Trial

By MedXY 09/17/2025

A 16-week randomized trial demonstrates that daily hydroxytyrosol supplementation significantly reduces oxidative stress and inflammatory markers in overweight individuals with prediabetes, highlighting its potential in preventing aging-related diseases.

Clinical Updates Wellness & Lifestyle

Electrical Vestibular Stimulation: A Promising Adjunct Therapy for Adult Insomnia in Hong Kong

By MedXY 09/17/2025

A double-blind, randomized trial demonstrates that electrical vestibular stimulation (VeNS) significantly reduces insomnia severity and improves quality of life in adults, highlighting a novel non-pharmacological treatment option.

Clinical Updates Wellness & Lifestyle

Enhancing Cognitive Function in Older Adults with Type 2 Diabetes: The Superior Effects of Tai Chi in a Mobile Health Trial

By MedXY 09/17/2025

This randomized controlled trial demonstrates that Tai Chi, combined with wearable device monitoring in a telemedicine model, significantly improves cognitive function and sleep quality in older adults with type 2 diabetes, outperforming fitness walking and usual care.

Clinical Updates Wellness & Lifestyle

Tai Chi and Cognitive Enhancement in Older Adults With Type 2 Diabetes Mellitus: Evidence From Randomized Controlled Trials Using Wearable Technology in mHealth Models

By MedXY 09/17/2025

Emerging RCT evidence supports Tai Chi's superior benefits over fitness walking in improving cognitive function and sleep quality among older adults with type 2 diabetes and mild cognitive impairment, facilitated by telemedicine and wearable devices.

Clinical Updates Wellness & Lifestyle

Add-on Probiotics for Inflammatory Depression: Insights from a Double-Blind Randomized Placebo-Controlled Trial

By MedXY 09/17/2025

This study evaluated the antidepressant effects of a Lactobacillus probiotic in overweight depressed patients with systemic low-grade inflammation, revealing no overall benefit but highlighting fecal formic acid as a potential biomarker for treatment response.

Clinical Updates Wellness & Lifestyle

Enhancing Vagal Nerve Function with Multi-Species Probiotics: A Promising Therapeutic Avenue for Major Depression

By MedXY 09/17/2025

A 3-month RCT demonstrates that multi-species probiotic supplementation improves vagal nerve function, gut microbiome composition, and sleep quality in patients with major depression, suggesting novel gut-brain axis interventions.

Clinical Updates Wellness & Lifestyle

Synergistic Effects of Combined Aerobic and Resistance Exercise with Diet on Insulin Secretion and Neurotrophic Factors in Older Adults with Obesity

By MedXY 09/17/2025

Combining aerobic and resistance exercise with diet-induced weight loss in older adults with obesity significantly improves insulin secretion, metabolic health, and physical function, likely mediated by ciliary neurotrophic factor receptor preservation and increased IGF-1 levels.

Clinical Updates Wellness & Lifestyle

SANA: A Novel Nitroalkene Salicylate Derivative Promoting Creatine-Dependent Thermogenesis and Weight Loss

By MedXY 09/17/2025

SANA, a nitroalkene derivative of salicylate, enhances creatine-dependent thermogenesis to reduce obesity and improve metabolic health, showing promising safety and efficacy in preclinical and early clinical studies.

Clinical Updates Wellness & Lifestyle

MAR001: A Promising ANGPTL4 Inhibitor for Safe and Effective Lipid Lowering

By MedXY 09/17/2025

Phase 1 and 1b/2a trials demonstrate that MAR001, an ANGPTL4 inhibitory antibody, safely reduces triglycerides and remnant cholesterol, supporting its potential to lower ASCVD risk beyond current therapies.

Clinical Updates Wellness & Lifestyle

Amycretin: A Promising First-in-Class Dual GLP-1 and Amylin Receptor Agonist for Overweight and Obesity

By MedXY 09/17/2025

Amycretin, a novel dual GLP-1 and amylin receptor agonist, demonstrated safety, tolerability, and dose-proportional pharmacokinetics in adults with overweight or obesity, supporting further trials on its weight loss efficacy.

Clinical Updates Wellness & Lifestyle

Enhancing Metformin Efficacy and Tolerability in Prediabetes Through a Fermentable Carbohydrate-Rich Diet

By MedXY 09/17/2025

A fermentable carbohydrate-enriched diet combined with metformin improves postprandial glycaemia, enhances GLP-1 secretion, and positively alters gut microbiota in prediabetic individuals, offering a personalized nutrition-pharmacology strategy for diabetes prevention.

Clinical Updates Wellness & Lifestyle

Unlocking Precision Nutrition: Genetic Insights from the MIND Diet Trial for Cognitive Health

By MedXY 09/16/2025

This article explores the genetic data resource from the MIND trial, highlighting its potential to tailor dietary interventions to mitigate cognitive decline and advance precision nutrition for Alzheimer's risk populations.

Clinical Updates Wellness & Lifestyle

Long-Term Outcomes of the DASH Intervention in Nonobstructive Coronary Artery Disease: Follow-Up of the DISCO-CT Study

By MedXY 09/16/2025

A one-year DASH diet intervention led to sustained suppression of proatherogenic chemokine CXCL4 and fewer major cardiovascular events over six years despite reduced adherence and partial loss of initial benefits in nonobstructive CAD patients.

Efficacy and Safety of cAMP-Biased GLP-1 Receptor Agonist Ecnoglutide Versus Dulaglutide in Type 2 Diabetes: Insights from the EECOH-2 Phase 3 Trial and Broader Clinical Context

Pitolisant as Adjunct Therapy for Refractory Restless Legs Syndrome: Insights from a Pilot Study

Camlipixant for Refractory Chronic Cough: Promising Phase 2b Trial Results and Clinical Implications

Bexotegrast Shows Promise in Treating Idiopathic Pulmonary Fibrosis: Insights from the INTEGRIS-IPF Phase 2a Trial

Optimizing Pyrazinamide Dosing in Drug-Susceptible Pulmonary Tuberculosis: Insights from a Large Phase 3 Trial

Lung-Protective Mechanical Ventilation in Acute Brain Injury: Insights from the PROLABI Trial

Optimizing Metabolic and Physical Health in Obese Older Adults: Impact of Exercise Modalities on Insulin Secretion, CNTF, and IGF-1 During Weight Loss

Hydroxytyrosol Supplementation Enhances Antioxidant and Anti-Inflammatory Status in Overweight Prediabetic Adults: Insights from a Randomized Controlled Trial

Electrical Vestibular Stimulation: A Promising Adjunct Therapy for Adult Insomnia in Hong Kong

Enhancing Cognitive Function in Older Adults with Type 2 Diabetes: The Superior Effects of Tai Chi in a Mobile Health Trial

Tai Chi and Cognitive Enhancement in Older Adults With Type 2 Diabetes Mellitus: Evidence From Randomized Controlled Trials Using Wearable Technology in mHealth Models

Add-on Probiotics for Inflammatory Depression: Insights from a Double-Blind Randomized Placebo-Controlled Trial

Enhancing Vagal Nerve Function with Multi-Species Probiotics: A Promising Therapeutic Avenue for Major Depression

Synergistic Effects of Combined Aerobic and Resistance Exercise with Diet on Insulin Secretion and Neurotrophic Factors in Older Adults with Obesity

SANA: A Novel Nitroalkene Salicylate Derivative Promoting Creatine-Dependent Thermogenesis and Weight Loss

MAR001: A Promising ANGPTL4 Inhibitor for Safe and Effective Lipid Lowering

Amycretin: A Promising First-in-Class Dual GLP-1 and Amylin Receptor Agonist for Overweight and Obesity

Enhancing Metformin Efficacy and Tolerability in Prediabetes Through a Fermentable Carbohydrate-Rich Diet

Unlocking Precision Nutrition: Genetic Insights from the MIND Diet Trial for Cognitive Health

Long-Term Outcomes of the DASH Intervention in Nonobstructive Coronary Artery Disease: Follow-Up of the DISCO-CT Study

Immunogenicity and Safety of the VLA15 Lyme Borreliosis Vaccine Across Age Groups: A Phase 2 Randomised Controlled Trial and Integrative Review

MACRO Trial Insights: Endoscopic Sinus Surgery Outperforms Clarithromycin in Chronic Rhinosinusitis Management

Adjunctive Corticosteroids in Severe Pneumocystis jirovecii Pneumonia Among HIV-negative Patients: Insights from a Multicentre Randomised Trial

Evaluating BDLC Regimen in Pre-XDR Tuberculosis: Findings from the endTB-Q Phase 3 Trial