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Dapagliflozin Shows Promising Benefits for Patients with Metabolic Dysfunction-Associated Steatohepatitis (MASH): A Landmark Multicentre Trial
Posted inClinical Updates Wellness & Lifestyle

Dapagliflozin Shows Promising Benefits for Patients with Metabolic Dysfunction-Associated Steatohepatitis (MASH): A Landmark Multicentre Trial

Posted by By MedXY 08/13/2025
Dapagliflozin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis outcomes without increasing adverse events, according to a rigorous 48-week randomized trial.
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Iloprost in Severe Septic Shock with Persistent Hypoperfusion: Insights from a Rigorous Randomized Trial
Posted inClinical Updates Wellness & Lifestyle

Iloprost in Severe Septic Shock with Persistent Hypoperfusion: Insights from a Rigorous Randomized Trial

Posted by By MedXY 08/13/2025
A recent double-blind RCT shows iloprost did not reduce organ failure severity in septic shock patients with persistent hypoperfusion, highlighting challenges in improving outcomes despite theoretical benefits in microcirculation.
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The Microcirculation in Pregnancy: Guardian of Health or Victim of Preeclampsia?
Posted inClinical Updates Wellness & Lifestyle

The Microcirculation in Pregnancy: Guardian of Health or Victim of Preeclampsia?

Posted by By MedXY 08/13/2025
This article explores how microcirculation functions as a key regulator in normal pregnancy but is compromised in preeclampsia, revealing early hemodynamic mechanisms behind gestational hypertension.
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Exploring Combined Finerenone and Empagliflozin Therapy in CKD and Type 2 Diabetes: Baseline Insights from the CONFIDENCE Trial
Posted inClinical Updates Wellness & Lifestyle

Exploring Combined Finerenone and Empagliflozin Therapy in CKD and Type 2 Diabetes: Baseline Insights from the CONFIDENCE Trial

Posted by By MedXY 08/13/2025
The CONFIDENCE trial evaluates whether combining finerenone with empagliflozin more effectively reduces urine albumin-to-creatinine ratio in CKD patients with type 2 diabetes compared to monotherapy, based on baseline characteristics of 818 diverse participants.
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Normosol-R versus Lactated Ringers in Critical Care: Evaluating Balanced Crystalloids for Optimal Patient Outcomes
Posted inClinical Updates Wellness & Lifestyle

Normosol-R versus Lactated Ringers in Critical Care: Evaluating Balanced Crystalloids for Optimal Patient Outcomes

Posted by By MedXY 08/13/2025
A randomized trial evaluating Normosol-R versus lactated Ringers in critically ill adults found no significant difference in acid-base balance, kidney replacement therapy rates, or 30-day mortality, supporting comparable efficacy between these balanced crystalloids.
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Regorafenib as Maintenance Therapy in Advanced Non-Adipocytic Soft Tissue Sarcomas: Positive Impact on Progression-Free Survival in a Randomised Trial
Posted inClinical Updates Wellness & Lifestyle

Regorafenib as Maintenance Therapy in Advanced Non-Adipocytic Soft Tissue Sarcomas: Positive Impact on Progression-Free Survival in a Randomised Trial

Posted by By MedXY 08/13/2025
The EREMISS trial demonstrates that regorafenib significantly prolongs progression-free survival as maintenance therapy after first-line doxorubicin chemotherapy in advanced non-adipocytic soft tissue sarcoma patients, with manageable safety profiles.
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Urine Biomarkers Predict Kidney Function Recovery After Ambulatory Acute Kidney Injury in Blood Pressure Treatment
Posted inClinical Updates Wellness & Lifestyle

Urine Biomarkers Predict Kidney Function Recovery After Ambulatory Acute Kidney Injury in Blood Pressure Treatment

Posted by By MedXY 08/13/2025
Urine biomarkers reflecting glomerular injury and tubular dysfunction can predict kidney function recovery after ambulatory acute kidney injury in hypertensive patients, aiding clinical decision-making during blood pressure management.
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Beta-blocker Interruption Effects on Blood Pressure and Heart Rate After Myocardial Infarction: The AβYSS Trial
Posted inClinical Updates Wellness & Lifestyle

Beta-blocker Interruption Effects on Blood Pressure and Heart Rate After Myocardial Infarction: The AβYSS Trial

Posted by By MedXY 08/13/2025
This study assesses the impact of β-blocker interruption on blood pressure and heart rate following myocardial infarction, revealing significant increases associated with treatment cessation, particularly in hypertensive patients.
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OPTIMAS Trial: Early vs. Delayed Anticoagulation in Acute Ischemic Stroke with Atrial Fibrillation and Chronic Kidney Disease
Posted inClinical Updates Wellness & Lifestyle

OPTIMAS Trial: Early vs. Delayed Anticoagulation in Acute Ischemic Stroke with Atrial Fibrillation and Chronic Kidney Disease

Posted by By MedXY 08/13/2025
The OPTIMAS trial shows that chronic kidney disease does not alter the safety or efficacy of early direct oral anticoagulant use after acute ischemic stroke with atrial fibrillation, supporting early initiation regardless of kidney status.
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Balancing Benefits and Harms of Intensive Blood Pressure Control Across Cardiovascular Risk Levels
Posted inClinical Updates Wellness & Lifestyle

Balancing Benefits and Harms of Intensive Blood Pressure Control Across Cardiovascular Risk Levels

Posted by By MedXY 08/12/2025
Intensive blood pressure control reduces cardiovascular events across all risk levels, with greater absolute benefits in higher-risk patients despite increased adverse events, supporting tailored treatment based on cardiovascular risk.
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Enhancing Prognosis in FSGS and MCD through Computational Tubular Feature Analysis
Posted inClinical Updates Wellness & Lifestyle

Enhancing Prognosis in FSGS and MCD through Computational Tubular Feature Analysis

Posted by By MedXY 08/12/2025
Computational quantification of tubular structures in kidney biopsies improves prognostic accuracy in focal segmental glomerulosclerosis and minimal change disease by revealing spatial relationships with interstitial fibrosis.
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Optimizing Hypertension Management Through Remote Monitoring: Insights from a Randomized Controlled Trial
Posted inClinical Updates Wellness & Lifestyle

Optimizing Hypertension Management Through Remote Monitoring: Insights from a Randomized Controlled Trial

Posted by By MedXY 08/11/2025
This study demonstrates the superior effectiveness of remote monitoring in reducing blood pressure among hypertensive patients compared to usual care and self-monitoring.
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Exploring the Link Between the Triglyceride-Glucose Index and Hypertension Incidence in Japanese Adults
Posted inClinical Updates Wellness & Lifestyle

Exploring the Link Between the Triglyceride-Glucose Index and Hypertension Incidence in Japanese Adults

Posted by By MedXY 08/11/2025
This study highlights the association between the triglyceride-glucose index and the incidence of hypertension in Japanese adults, emphasizing its potential as a predictive marker for cardiovascular health.
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Revisiting Women’s Health: Pregnancy Complications and Long-Term Stroke Risk
Posted inClinical Updates Wellness & Lifestyle

Revisiting Women’s Health: Pregnancy Complications and Long-Term Stroke Risk

Posted by By MedXY 08/11/2025
This article explores the associations between pregnancy complications and the risk of ischemic stroke in young women, highlighting the importance of early identification for preventive measures.
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Examining the Link Between Obesity and Kidney Outcomes in Heart Failure with Preserved Ejection Fraction
Posted inClinical Updates Wellness & Lifestyle

Examining the Link Between Obesity and Kidney Outcomes in Heart Failure with Preserved Ejection Fraction

Posted by By MedXY 08/11/2025
A pooled analysis of four heart failure trials explores the relationship between obesity and kidney outcomes, revealing waist circumference and waist-to-height ratio as key risk factors, while body mass index showed no significant association.
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Improving Patient Safety: The Role of Deprescribing Diabetes Medication in Older Adults
Posted inClinical Updates Wellness & Lifestyle

Improving Patient Safety: The Role of Deprescribing Diabetes Medication in Older Adults

Posted by By MedXY 08/11/2025
This study examines the effectiveness of physician academic detailing combined with previsit patient activation to increase diabetes medication deprescribing amongst older adults, aiming to reduce hypoglycemia-related complications.
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Exploring Auricular Acupressure: A Promising Complementary Intervention for Older Adults with Type 2 Diabetes
Posted inClinical Updates Wellness & Lifestyle

Exploring Auricular Acupressure: A Promising Complementary Intervention for Older Adults with Type 2 Diabetes

Posted by By MedXY 08/11/2025
A recent study investigates auricular acupressure's effects on glycemic markers, stress, and sleep quality in older adults with Type 2 diabetes, revealing promising outcomes and potential for nursing interventions.
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Assessing an AI Chatbot for HIV Prevention in Malaysia: Insights and Usability
Posted inClinical Updates Wellness & Lifestyle

Assessing an AI Chatbot for HIV Prevention in Malaysia: Insights and Usability

Posted by By MedXY 08/11/2025
An observational study evaluates an AI chatbot's usability in promoting HIV testing among men who have sex with men in Malaysia, showcasing potential improvements for public health interventions.
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Revolutionizing Wound Healing Assessment: The Role of LC-OCT and AI
Posted inClinical Updates Wellness & Lifestyle

Revolutionizing Wound Healing Assessment: The Role of LC-OCT and AI

Posted by By MedXY 08/11/2025
This study explores the integration of line-field confocal optical coherence tomography (LC-OCT) with artificial intelligence (AI) to enhance wound healing evaluations, providing deeper insights into clinical interventions.
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Long-Term Safety of Antenatal Corticosteroids: Insights from the 50-Year Follow-Up of the Auckland Steroid Trial
Posted inClinical Updates Wellness & Lifestyle

Long-Term Safety of Antenatal Corticosteroids: Insights from the 50-Year Follow-Up of the Auckland Steroid Trial

Posted by By MedXY 08/11/2025
The 50-year follow-up study on the Auckland Steroid Trial provides reassurance about the intergenerational safety of antenatal corticosteroid exposure concerning body mass index and various health outcomes in the second generation.
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  • Aspirin vs. Clopidogrel Monotherapy Following PCI: Insights from the STOPDAPT-3 1-Year Follow-up
  • Aspirin-Free Strategy in High Bleeding Risk PCI Patients: Insights from STOPDAPT-3 Subgroup Analysis
  • Comparing Cardiac MRI and Coronary Angiography for Diagnosing Ischemic Cardiomyopathy in New-Onset Heart Failure
  • Intranasal Mesenchymal Stromal Cells for Perinatal Arterial Stroke: Promising Safety and Improved Neurodevelopment at Two Years
  • RNS60 as Adjunctive Therapy in Acute Large Vessel Occlusion Stroke: Insights from the RESCUE Trial
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