Psychedelics Target Neuroimmune Interactions to Limit Fear
Research reveals how psychedelics modulate immune-to-brain communication to reduce fear, offering new therapeutic avenues for stress-related psychiatric disorders.
Posted inClinical Updates news Orthopedics Specialties
Exercise Alone Matches Diet Plus Exercise for Hip Osteoarthritis Pain Relief, Large Randomized Trial Shows
Adding a very-low-calorie diet to exercise yields no additional pain relief for overweight or obese adults with hip osteoarthritis, despite greater weight loss.
Posted inAI Clinical Updates news Specialties
Artificial Intelligence in Clinical Trials: Building a Value-Based Framework for Effective Adoption
AI offers transformative potential for clinical trials, but realizing its value demands a robust, stakeholder-driven framework to guide adoption and assess impact across the trial lifecycle.
Evaluation of ChatGPT-4 as an Online Outpatient Assistant in Puerperal Mastitis Management: An Observational Study Analysis
This study assesses ChatGPT-4's effectiveness as a virtual assistant in managing puerperal mastitis, focusing on accuracy, clarity, and safety in patient communication.
Posted inClinical Updates news Pediatrics Specialties
Darbepoetin in Preterm Infants: Enhancing Red Cell Mass without Neurodevelopmental Benefit
Weekly darbepoetin in extremely preterm infants increases red cell mass and reduces transfusion needs, but does not improve cognitive outcomes at 22-26 months' corrected age.
Posted inClinical Updates news Psychiatry Specialties
Do Safety Planning Interventions Reduce Suicide Risk in Adolescents? Insights from a Systematic Review and Meta-Analysis
Recent meta-analysis finds no significant benefit of standalone safety planning interventions in reducing suicidal ideation or behavior among adolescents, highlighting the need for more robust research.
Empowering Parents: Acceptance and Commitment Therapy for Children With Asthma and ADHD
A randomized clinical trial demonstrates that an Acceptance and Commitment Therapy-based parenting program reduces health care use, improves asthma control, and alleviates ADHD symptoms in children with both conditions.
Posted inCardiology Clinical Updates news Specialties
DASH4D Trial: Dietary Patterns and Sodium Reduction for Blood Pressure Control in Type 2 Diabetes
The DASH4D trial demonstrates that sodium reduction, alongside a tailored DASH diet, significantly lowers blood pressure in adults with type 2 diabetes, most of whom already use multiple antihypertensive medications.
Intensive Nurse Home Visiting and Early Childhood Outcomes: A Randomized Clinical Trial
A randomized trial assessing the impact of Nurse-Family Partnership home visits on child health and utilization over two years found no significant reduction in adverse outcomes but some decrease in emergency department use.
Posted inCardiology Clinical Updates Specialties
Heart Failure Risk with Pregabalin vs Gabapentin: New Evidence for Chronic Pain Management in Older Adults
New data show an increased risk of heart failure among elderly Medicare patients initiating pregabalin versus gabapentin for chronic noncancer pain, particularly in those with cardiovascular disease history.
Regulation of Cues vs Cognitive Behavioral Therapy: Advancing Binge Eating Disorder Treatment for Veterans
ROC plus behavioral weight loss outperformed CBT in reducing binge eating among veterans, with transient advantages in weight loss. Long-term weight outcomes require further research.
Therapeutic Strategies for Disease-Modifying Therapy Management in Pregnant Women With Multiple Sclerosis: Relapse Risk and Clinical Implications
Managing disease-modifying therapies (DMTs) during pregnancy in women with multiple sclerosis significantly affects relapse risk, with anti-CD20 strategies demonstrating superior protection compared to other approaches.
Supplemental Donor Milk versus Infant Formula for Moderate to Late Preterm Infants: Implications from a Multisite Randomized Trial
A multisite RCT found no difference in time to full enteral feeds between donor human milk and formula in moderate to late preterm infants, but formula was associated with faster weight regain.
Posted inClinical Updates news Oncology Specialties
Cannabis Use Disorder Linked to Elevated Risk of Benign Salivary Gland Tumors: New Insights from a Large Retrospective Cohort Study
A large US-based study found a greater than fivefold increased risk of benign salivary gland tumors, especially parotid tumors, in individuals with cannabis use disorder.
Posted inClinical Updates news Pediatrics Specialties
Does Treating Older Siblings Enhance the Impact of Azithromycin on Infant Survival? Insights from a Cluster-Randomized Trial in Niger
Mass azithromycin administration to both infants and older children reduced infant mortality more than treating infants alone, with potential spillover benefits from treating older siblings.
Posted inClinical Updates news
Optimizing Daptomycin Use in Japanese Pediatric Patients: The Critical Roles of Dose and Renal Function
A multicenter study in Japan found that adequate daptomycin dosing significantly improves clinical outcomes in pediatric patients, while adverse events can occur regardless of renal function.
Posted inClinical Updates news
Perinatal Antibiotic Exposure Alters Neonatal Gut Microbiota in Preterm Infants: Clinical Implications for Infection Risk and Microbial Maturation
Perinatal antibiotic exposure in preterm infants disrupts gut microbiota composition, increasing pathogenic bacteria and reducing beneficial species, with implications for infection risk and the protective role of breastfeeding.
Posted inClinical Updates news
Disparities in Inpatient Antibiotic Use for Pediatric Pneumonia: Minority and Low-Opportunity Children at Higher Risk of Overtreatment
Minority children and those from lower socioeconomic backgrounds receive significantly more and broader-spectrum antibiotics for pneumonia during hospitalization than non-Hispanic White counterparts, contrary to outpatient trends.
Posted inClinical Updates news Oncology Specialties
A Century of Change: How Human Innovation Transformed Lung Cancer Treatment
Lung cancer therapy has evolved from rudimentary surgery and misdiagnosis to a precision medicine era, markedly improving outcomes through targeted therapies and immunotherapy.
Posted inClinical Updates Neurology news Specialties
Trehalose in ALS: No Efficacy Shown in the HEALEY ALS Platform Trial
Trehalose was safe but did not slow ALS progression compared to placebo in a large, adaptive phase 2/3 trial.