Elinzanetant: A Novel Non-Hormonal Neurokinin 1 and 3 Receptor Antagonist Transforming Menopausal Vasomotor Symptom Management
Posted inClinical Updates news OB/GYN & Women's Health

Elinzanetant: A Novel Non-Hormonal Neurokinin 1 and 3 Receptor Antagonist Transforming Menopausal Vasomotor Symptom Management

Elinzanetant, approved in the UK in July 2025 and by the FDA in October 2025, is the first non-hormonal NK1 and NK3 receptor antagonist for moderate-to-severe menopausal vasomotor symptoms, demonstrated effective and safe in pivotal phase 2b/3 trials with added benefits on sleep and quality of life.
Early Clinical Evaluation of Novel Broadly Neutralising Monoclonal Antibodies for HIV-1: Safety, Pharmacokinetics, and Neutralisation Profiles of N6LS, PGDM1400LS, and PGT121.414.LS
Posted inClinical Updates HIV/AIDS news

Early Clinical Evaluation of Novel Broadly Neutralising Monoclonal Antibodies for HIV-1: Safety, Pharmacokinetics, and Neutralisation Profiles of N6LS, PGDM1400LS, and PGT121.414.LS

This review summarizes early-phase clinical trials assessing the safety, pharmacokinetics, and neutralisation activity of three innovative broadly neutralising monoclonal antibodies—N6LS, PGDM1400LS, and PGT121.414.LS—for HIV-1 prevention and therapy.
Linerixibat for Cholestatic Pruritus in Primary Biliary Cholangitis: Insights from the Phase 3 GLISTEN Trial and Related Studies
Posted inClinical Updates Gastroenterology news

Linerixibat for Cholestatic Pruritus in Primary Biliary Cholangitis: Insights from the Phase 3 GLISTEN Trial and Related Studies

This review synthesizes evidence from the phase 3 GLISTEN trial and preceding studies on linerixibat, an ileal bile acid transporter inhibitor, demonstrating its efficacy and safety in reducing cholestatic pruritus in primary biliary cholangitis (PBC), and its impact on patient quality of life.
Longitudinal Developmental Outcomes and Early Cochlear Implantation Benefits in Children with Prelingual Single-Sided Deafness: Evidence Synthesis and Clinical Recommendations
Posted inClinical Updates news Otorhinolaryngology Pediatrics

Longitudinal Developmental Outcomes and Early Cochlear Implantation Benefits in Children with Prelingual Single-Sided Deafness: Evidence Synthesis and Clinical Recommendations

Early cochlear implantation in children with prelingual single-sided deafness improves spatial hearing and cognitive outcomes, supporting neurodevelopment and mitigating risks of auditory deprivation and cortical reorganization.
Cardiovascular and Respiratory Responses During Graded Exercise in Adolescents After Sport-Related Concussion: A Synthesis of Current Evidence
Posted inCardiology Clinical Updates news Rehabilitation Medicine Respiratory

Cardiovascular and Respiratory Responses During Graded Exercise in Adolescents After Sport-Related Concussion: A Synthesis of Current Evidence

Exploring altered cardiopulmonary dynamics and exercise intolerance in adolescents post-sport-related concussion reveals attenuated cardiovascular responses independent of aerobic deconditioning, highlighting autonomic dysregulation as a key mechanism.
Online Unsupervised Tai Chi Intervention for Knee Osteoarthritis: Insights from the RETREAT Randomized Clinical Trial and Systematic Reviews
Posted inClinical Updates Family Medicine & Nutrition news Orthopedics

Online Unsupervised Tai Chi Intervention for Knee Osteoarthritis: Insights from the RETREAT Randomized Clinical Trial and Systematic Reviews

This review synthesizes evidence from the RETREAT RCT and past systematic reviews, highlighting that an unsupervised online Tai Chi program significantly improves knee pain and function in knee osteoarthritis, providing a scalable, accessible exercise option.
Evaluating AI-Led vs Human-Led Lifestyle Interventions in Prediabetes: Evidence from a Randomized Clinical Trial of the Diabetes Prevention Program
Posted inAI Clinical Updates Diabetes & Endocrinology news

Evaluating AI-Led vs Human-Led Lifestyle Interventions in Prediabetes: Evidence from a Randomized Clinical Trial of the Diabetes Prevention Program

This review examines the first phase 3 randomized trial demonstrating that an AI-powered Diabetes Prevention Program lifestyle intervention is noninferior to human coaching in improving weight loss, HbA1c, and physical activity among adults with prediabetes and overweight or obesity.
Optimizing Gonorrhea and Chlamydia Screening for Adolescents in Emergency Departments: Evidence from Targeted and Universal Strategies
Posted inClinical Updates Emergency Medicine Infectious Diseases news Pediatrics Public Health

Optimizing Gonorrhea and Chlamydia Screening for Adolescents in Emergency Departments: Evidence from Targeted and Universal Strategies

Comparative effectiveness evidence from multicenter pediatric emergency departments demonstrates that targeted and universally offered gonorrhea and chlamydia screening increase detection rates versus usual care, highlighting the need for integrated ED screening protocols in adolescents.