Advanced Liver Imaging Reveals Impaired Postprandial Hepatic Glucose Handling and Hidden Metabolic Subtypes in Type 1 Diabetes

Highlights

Adults with type 1 diabetes showed a larger postprandial rise in hepatic deuterium-labeled glucose than matched healthy control individuals, despite similar systemic insulin exposure.

Healthy control individuals demonstrated clear hepatic glycogen accumulation after oral glucose, whereas the type 1 diabetes group showed no significant glycogen rise by 150 minutes.

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