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In this multi-institutional retrospective cohort of 1,954 patients with adrenal incidentaloma and mild autonomous cortisol secretion (MACS), adrenalectomy was associated with a markedly lower hazard of all-cause mortality compared with nonoperative management after propensity score matching.
Adrenalectomy was also associated with a lower risk of new-onset diabetes, whereas differences in ischemic heart disease, cerebral infarction, fracture, and hypertension were not statistically significant.
