LMNA Variant Type and Location Shape Arrhythmic Risk in Cardiomyopathy: Truncations Confer Higher VA Risk; Tail-domain Missense Variants Appear Lower Risk
Posted inCardiology news

LMNA Variant Type and Location Shape Arrhythmic Risk in Cardiomyopathy: Truncations Confer Higher VA Risk; Tail-domain Missense Variants Appear Lower Risk

In 718 patients with pathogenic/likely pathogenic LMNA variants, truncating variants carried higher risk of malignant ventricular arrhythmia independent of position, while missense variants in the tail domain and exons 7–12 had lower arrhythmic and heart-failure events, suggesting genotype-location refines risk stratification.
Shared Genetic Vulnerability: Polygenic and Monogenic Contributions to Peripartum, Alcohol-Induced, and Cancer Therapy–Related Cardiomyopathies
Posted inCardiology news

Shared Genetic Vulnerability: Polygenic and Monogenic Contributions to Peripartum, Alcohol-Induced, and Cancer Therapy–Related Cardiomyopathies

A large multi-cohort genetic analysis shows that both rare monogenic variants and a high polygenic score for dilated cardiomyopathy (DCM) are enriched in peripartum, alcohol-induced, and cancer therapy–related cardiomyopathies, supporting a shared genetic susceptibility unmasked by diverse environmental stressors.
Common, Rare and Somatic Genetic Drivers Together Double 5‑Year Atrial Fibrillation Risk: Toward an Integrated Genomic Model (IGM‑AF)
Posted inCardiology news Pathology & Lab Medicine

Common, Rare and Somatic Genetic Drivers Together Double 5‑Year Atrial Fibrillation Risk: Toward an Integrated Genomic Model (IGM‑AF)

A UK Biobank whole‑genome study finds polygenic, rare monogenic, and somatic (CHIP) variants each independently associate with incident atrial fibrillation (AF); combined genomic profiling plus clinical risk (CHARGE‑AF) improves discrimination (C=0.80) and reclassification.
Intracardiac Echocardiography Is Noninferior to Transesophageal Echocardiography for Thrombus Screening in Atrial Fibrillation Ablation — with Added Safety and Efficiency Gains
Posted inCardiology news

Intracardiac Echocardiography Is Noninferior to Transesophageal Echocardiography for Thrombus Screening in Atrial Fibrillation Ablation — with Added Safety and Efficiency Gains

A multicenter randomized trial (N=1,810) found intracardiac echocardiography (ICE) noninferior to transesophageal echocardiography (TEE) for preventing periprocedural thromboembolism in AF ablation, while reducing bleeding related to transseptal puncture, fluoroscopy time, preprocedural wait, and patient anxiety.
Sự viêm vi mạch bẩm sinh sớm và kích hoạt nội mô xác định đặc điểm miễn dịch chủng khác sau ghép tim lợn sang người
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Sự viêm vi mạch bẩm sinh sớm và kích hoạt nội mô xác định đặc điểm miễn dịch chủng khác sau ghép tim lợn sang người

Phân tích đa chế độ của hai quả tim lợn đã được chỉnh sửa gen 10 gen được ghép vào người đã chết não cho thấy sự viêm vi mạch bẩm sinh sớm với kích hoạt nội mô và hồ sơ phân tử phù hợp với tổn thương do kháng thể mặc dù không có C4d trong mao mạch. Một cách tiếp cận chẩn đoán chính xác có thể cải thiện giám sát ghép.
Early Innate Microvascular Inflammation and Endothelial Activation Define the Xenoimmune Signature After Pig-to-Human Heart Transplantation
Posted inCardiology news

Early Innate Microvascular Inflammation and Endothelial Activation Define the Xenoimmune Signature After Pig-to-Human Heart Transplantation

Multimodal analysis of two 10-gene–edited pig hearts transplanted into brain-dead human recipients revealed early innate microvascular inflammation with endothelial activation and a molecular profile consistent with antibody-mediated injury despite absent capillary C4d. A precision diagnostic approach may improve graft surveillance.
Elevated Blood Pressure in Adolescence Predicts Dose‑Dependent Coronary Atherosclerosis in Middle Age: Implications for Early Detection and Prevention
Posted inCardiology news Pediatrics Public Health

Elevated Blood Pressure in Adolescence Predicts Dose‑Dependent Coronary Atherosclerosis in Middle Age: Implications for Early Detection and Prevention

A Swedish cohort study of 10,222 men linked adolescent blood pressure to coronary atherosclerosis by CCTA ~40 years later; higher systolic BP in adolescence, even in the ‘elevated’ range, was associated with greater odds of severe (>50%) coronary stenosis in middle age.
Underweight in Type 2 Diabetes Raises Cardiovascular Risk — Severe Leanness Carries Greater Risk Than Obesity
Posted inCardiology Diabetes & Endocrinology news

Underweight in Type 2 Diabetes Raises Cardiovascular Risk — Severe Leanness Carries Greater Risk Than Obesity

A nationwide Korean cohort found that underweight patients with Type 2 diabetes—especially those with severe underweight—have higher cardiovascular risk than normal-weight and even some obese patients, underscoring the need to screen and manage malnutrition, sarcopenia, and frailty in diabetes care.
Excessive Glycosylation and the HBP–ISR Axis: A Metabolic Driver of Thoracic Aortic Aneurysm with Therapeutic Implications
Posted inCardiology news

Excessive Glycosylation and the HBP–ISR Axis: A Metabolic Driver of Thoracic Aortic Aneurysm with Therapeutic Implications

A preclinical and human tissue study shows up-regulation of the hexosamine biosynthetic pathway and downstream integrated stress response in thoracic aortic aneurysm, linking excessive glycosylation to vascular smooth muscle cell dysfunction and medial degeneration; pharmacologic inhibition reverses disease features in a Marfan model.
METTL14 and LATS1/2 Define Divergent Endothelial Programs That Drive Vascular Ageing and Atherothrombosis — New Therapeutic Nodes in Cardio‑Vascular Senescence
Posted inCardiology news

METTL14 and LATS1/2 Define Divergent Endothelial Programs That Drive Vascular Ageing and Atherothrombosis — New Therapeutic Nodes in Cardio‑Vascular Senescence

Two complementary studies identify METTL14/TLR4 and LATS1/2–CD38–SUOX axes as key drivers of endothelial senescence phenotypes that promote arterial ageing, stiffness, fragile neovessels and atherothrombotic plaque formation, highlighting new biomarker and therapeutic opportunities.
Real-time Sepsis Risk Prediction in Acute Gastrointestinal Bleeding: A Validated Dynamic Monitoring Tool That Improves Early Stratification
Posted inCritical Care Gastroenterology news

Real-time Sepsis Risk Prediction in Acute Gastrointestinal Bleeding: A Validated Dynamic Monitoring Tool That Improves Early Stratification

A multicenter Chinese study developed and validated a real-time nomogram that predicts sepsis in acute gastrointestinal bleeding (AGIB) using clinical and laboratory variables; the tool showed strong discrimination (AUCs 0.827–0.884), good calibration, and an online monitoring platform for dynamic alerts.