Urolithin A in Elite Distance Runners: Improves Recovery and Perceived Effort but Not Race Performance in 4-Week Altitude Training
Posted inInternal Medicine news Public Health

Urolithin A in Elite Distance Runners: Improves Recovery and Perceived Effort but Not Race Performance in 4-Week Altitude Training

A randomized, placebo-controlled trial in highly trained male distance runners found 4 weeks of 1000 mg/day urolithin A reduced markers of muscle damage and perceived exertion and upregulated mitochondrial proteomic pathways, but did not produce statistically significant performance gains in a 3000 m time trial.
Hearing Aids Improve Some Aspects of Socio-Emotional Well‑being — But Not All: Insights from the WHAM Longitudinal Study
Posted innews Otorhinolaryngology

Hearing Aids Improve Some Aspects of Socio-Emotional Well‑being — But Not All: Insights from the WHAM Longitudinal Study

The WHAM longitudinal study finds modest psychosocial benefits from hearing‑aid uptake—reduced depression in people without tinnitus and lower loneliness in older adults—while showing limited mediation by self-perceived hearing disability and minimal effects of use duration or daily wearing hours.
Belantamab Mafodotin Plus Bortezomib and Dexamethasone Significantly Improves Overall Survival in Relapsed/Refractory Multiple Myeloma: Updated DREAMM-7 Results
Posted inHematology-Oncology news

Belantamab Mafodotin Plus Bortezomib and Dexamethasone Significantly Improves Overall Survival in Relapsed/Refractory Multiple Myeloma: Updated DREAMM-7 Results

The DREAMM-7 phase 3 trial shows that belantamab mafodotin combined with bortezomib and dexamethasone produces early, sustained, and statistically significant overall survival and deep, durable responses versus daratumumab-based therapy in relapsed/refractory multiple myeloma.
Vorasidenib Slows Tumour Growth and Reduces Seizures in IDH‑Mutant Grade 2 Glioma — Robust PFS and Preserved Cognition in the INDIGO Phase 3 Trial
Posted inNeurology news Oncology

Vorasidenib Slows Tumour Growth and Reduces Seizures in IDH‑Mutant Grade 2 Glioma — Robust PFS and Preserved Cognition in the INDIGO Phase 3 Trial

In the INDIGO phase 3 trial, vorasidenib markedly prolonged progression‑free survival and time to next intervention, reduced volumetric tumour growth and seizure burden, and preserved quality of life and neurocognitive function in patients with grade 2 IDH1/2‑mutant diffuse glioma after surgery.
Cochlear Implant Benefits in Children with Single‑Sided Deafness: Better in Quiet, Challenged in Noise — and Time Matters
Posted innews Otorhinolaryngology Pediatrics

Cochlear Implant Benefits in Children with Single‑Sided Deafness: Better in Quiet, Challenged in Noise — and Time Matters

In 185 children receiving unilateral cochlear implants, residual acoustic hearing favored the non-implanted ear in quiet (especially for SSD), but noise attenuated that advantage. Shorter auditory deprivation and longer CI experience reduced asymmetry and increased bilateral benefit, underscoring the value of early intervention.
Longitudinal Developmental Outcomes and Early Cochlear Implantation Benefits in Children with Prelingual Single-Sided Deafness: Evidence Synthesis and Clinical Recommendations
Posted inClinical Updates news Otorhinolaryngology Pediatrics

Longitudinal Developmental Outcomes and Early Cochlear Implantation Benefits in Children with Prelingual Single-Sided Deafness: Evidence Synthesis and Clinical Recommendations

Early cochlear implantation in children with prelingual single-sided deafness improves spatial hearing and cognitive outcomes, supporting neurodevelopment and mitigating risks of auditory deprivation and cortical reorganization.
Early Cochlear Implantation Shows Variable but Clinically Relevant Benefits in Children with Single-Sided Deafness: A Western Australian 10‑Year Series
Posted innews Otorhinolaryngology Pediatrics

Early Cochlear Implantation Shows Variable but Clinically Relevant Benefits in Children with Single-Sided Deafness: A Western Australian 10‑Year Series

A retrospective 10‑year series from Perth Children's Hospital reports heterogeneous long‑term outcomes after pediatric cochlear implantation for single‑sided deafness; earlier implantation (within 1 year) was associated with greater likelihood of benefit in speech‑in‑noise and localization.
Targeting Mitochondria: A Practical Algorithm for Diabetes Care in Maternally Inherited Diabetes and Deafness (MIDD)
Posted inDiabetes & Endocrinology news

Targeting Mitochondria: A Practical Algorithm for Diabetes Care in Maternally Inherited Diabetes and Deafness (MIDD)

Maternally inherited diabetes and deafness (MIDD) is driven by m.3243A>G mitochondrial mutation with mixed β‑cell failure and insulin resistance. GLP‑1 receptor agonists and SGLT2 inhibitors have biologic plausibility and cardiorenal benefits in MIDD; we propose a pathophysiology‑driven treatment algorithm and practical monitoring guidance.
Clear, Safe, Sustainable: Expert Consensus on Dietary Strategies to Change Body Mass and Composition in Athletes (Scoping Review Summary)
Posted innews Public Health Rehabilitation Medicine

Clear, Safe, Sustainable: Expert Consensus on Dietary Strategies to Change Body Mass and Composition in Athletes (Scoping Review Summary)

A practical, evidence-focused synthesis of 73 international consensus statements and position stands (Delany et al., 2025). Key takeaways: individualise targets, protect health (EA ≥30 kcal/kg FFM/day), use gradual rates, prioritise protein (≈1.6–2.4 g/kg/day), periodise carbohydrate, and be conservative with supplements.
Unraveling Hamstring Injury Mechanisms and Eccentric Training Adaptations: Integrative Insights and Future Preventive Strategies
Posted innews Orthopedics Rehabilitation Medicine

Unraveling Hamstring Injury Mechanisms and Eccentric Training Adaptations: Integrative Insights and Future Preventive Strategies

Hamstring injuries mainly occur during the late swing phase of running due to high eccentric forces and neural factors. Eccentric training reduces injury risk through complex muscle adaptations involving contractile, non-contractile, and neural components. Further research is essential to optimize prevention.