news – Page 32 – Medxy AI

Cannabidiol Use and Liver Enzyme Elevations: Insights from a Randomized Clinical Trial in Healthy Adults

By MedXY 09/11/2025

A 4-week randomized trial shows that low-dose cannabidiol (CBD) may cause transient liver enzyme elevations in healthy adults, emphasizing the need for vigilance and further safety assessment of consumer CBD products.

Clinical Updates news

Metformin and COVID-19 Symptom Resolution: Evidence from the ACTIV-6 Randomized Clinical Trial

By MedXY 09/11/2025

This review synthesizes recent evidence from the ACTIV-6 trial showing metformin does not significantly reduce symptom duration in low-risk adults with COVID-19, addressing safety, clinical outcomes, and translational insights.

Clinical Updates news Psychiatry Specialties

Enhancing Opioid Use Disorder Care in Primary Settings: Impact of an EHR-Integrated Clinical Decision Support System

By MedXY 09/11/2025

A cluster randomized trial demonstrates that an electronic health record–integrated clinical decision support system increases naloxone prescriptions and opioid use disorder treatments in primary care but does not change diagnosis rates or MOUD adherence.

Clinical Updates Neurology news Specialties Urology

Behavioral Therapy Matches Drug Efficacy for Overactive Bladder in Parkinson’s Disease: Insights from a Randomized Noninferiority Trial

By MedXY 09/11/2025

A 12-week randomized trial demonstrates that behavioral therapy is noninferior to solifenacin in treating overactive bladder symptoms in Parkinson disease, with fewer adverse effects, supporting behavioral therapy as a frontline treatment option.

Clinical Updates Neurology news

Inflammatory Exposure Amplifies Depressive Symptoms in Older Adults with Insomnia: Insights from a Randomized Clinical Trial

By MedXY 09/11/2025

A randomized clinical trial reveals older adults with insomnia have heightened depressive responses to inflammatory challenge, underscoring the need for targeted depression monitoring and prevention strategies in this vulnerable population.

Clinical Updates General Surgery news Specialties

Fiber-Based Near-Infrared Autofluorescence Enhances Parathyroid Identification in Endocrine Neck Surgery Without Reducing Hypoparathyroidism Risk

By MedXY 09/11/2025

This multicenter randomized clinical trial demonstrates that fiber-based near-infrared autofluorescence (NIRAF) enhances intraoperative parathyroid gland identification during thyroidectomy and bilateral parathyroidectomy without increasing hypoparathyroidism rates or operative time.

General Surgery news OB/GYN & Women's Health Specialties

Open Anterior Mesh Repair Versus Modified Technique for Groin Hernia in Women: Insights from a Ugandan Randomized Trial

By MedXY 09/11/2025

A randomized clinical trial in Uganda compared standard open anterior mesh repair with a modified technique addressing femoral hernias, demonstrating both methods as safe and effective options for women's groin hernia repair in low-resource settings.

Clinical Updates news Pediatrics Specialties

Deferred Cord Clamping with High Oxygen in Extremely Preterm Infants: Enhancing Early Oxygenation Without Added Morbidity

By MedXY 09/10/2025

This review examines randomized clinical evidence that 100% oxygen during deferred cord clamping improves early oxygen saturation in extremely preterm infants without increasing morbidity, highlighting implications for neonatal resuscitation practice.

Cardiology Diabetes & Endocrinology news Specialties

Impact of Diabetes and Obesity on Early Rhythm Control Outcomes in Atrial Fibrillation: Insights from the EAST-AFNET 4 Trial

By MedXY 09/10/2025

A secondary analysis of the EAST-AFNET 4 trial shows early rhythm control therapy effectively reduces cardiovascular events in atrial fibrillation patients regardless of diabetes status or obesity, supporting its broad clinical use.

news OB/GYN & Women's Health Pediatrics Specialties

In Utero Embolization for Fetal Vein of Galen Malformation: Early Clinical Insights and Outcomes

By MedXY 09/10/2025

This article reviews early clinical results from a US single-center study on in utero embolization for fetal Vein of Galen malformation, highlighting potential survival benefits alongside risks of preterm delivery.

Family Medicine & Nutrition news Specialties

Human Telephone vs. Text Message Counseling: Increasing Physical Activity in Midlife and Older Hispanic Adults

By MedXY 09/10/2025

A randomized clinical trial demonstrates that customizable SMS counseling is as effective as human telephone counseling in increasing 12-month walking activity among inactive Hispanic or Latino/a adults, offering scalable options for public health interventions.

Clinical Updates Neurology news OB/GYN & Women's Health Specialties

Innovations in Prenatal Care: In Utero Embolization for Vein of Galen Malformation

By MedXY 09/10/2025

In utero embolization for fetal Vein of Galen malformation shows early promise in reducing mortality and neurodevelopmental delays, despite increased risk of preterm delivery.

Cardiology Clinical Updates news Nursing & care Specialties

Multidomain Rehabilitation Reduces Cardiovascular Events in Older Adults Post-Myocardial Infarction: Insights from the PIpELINe Trial

By MedXY 09/10/2025

A multidomain rehabilitation program combining cardiovascular risk control, dietary counseling, and exercise significantly lowers the risk of cardiovascular death or unplanned hospitalization within one year in older myocardial infarction survivors with impaired physical performance.

Cardiology news Specialties

Evaluating Mavacamten in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy: Insights from the ODYSSEY-HCM Trial

By MedXY 09/10/2025

A phase 3 trial found mavacamten did not significantly improve exercise capacity or symptoms in adults with symptomatic nonobstructive hypertrophic cardiomyopathy compared to placebo, despite its efficacy in obstructive HCM.

news Respiratory Specialties

Evaluating Carbocysteine in Mild-to-Moderate COPD: Insights From a Large Multicenter Controlled Trial

By MedXY 09/10/2025

A large phase 4 trial found carbocysteine did not significantly reduce exacerbation rates or improve lung function in mild-to-moderate COPD, suggesting limited benefit beyond severe cases.

Diabetes & Endocrinology news Specialties

Automated Insulin Delivery in Insulin-Treated Type 2 Diabetes: A Comprehensive Review of Randomized Controlled Trial Evidence and Clinical Implications

By MedXY 09/10/2025

Automated insulin delivery (AID) significantly improves glycemic control in insulin-treated type 2 diabetes, demonstrating greater HbA1c reduction and increased time in target glucose range compared to traditional insulin delivery methods.

Clinical Updates Hematology-Oncology news Pathology & Lab Medicine Specialties

Ultrasensitive Circulating Tumor DNA as a Superior Biomarker for Remission Assessment in Large B-cell Lymphoma

By MedXY 09/10/2025

Detection of circulating tumor DNA (ctDNA) provides a highly prognostic method for assessing remission in large B-cell lymphoma, outperforming conventional imaging and promising improved patient outcomes.

Clinical Updates Hematology-Oncology news Specialties

Reversing PD-1 Resistance in Advanced Melanoma: Insights from the SPOTLIGHT-203 Phase II Trial of BO-112 Plus Pembrolizumab

By MedXY 09/10/2025

The SPOTLIGHT-203 Phase II trial demonstrates that intratumoral BO-112 combined with pembrolizumab shows promise by achieving a 25% ORR in anti-PD-1-resistant advanced melanoma with manageable safety, offering a potential new therapeutic avenue.

Clinical Updates news Oncology Specialties

Prognostic Role of HER2 Amplification and Mutations in Metastatic Colorectal Cancer: Insights from Eight Randomized Trials

By MedXY 09/10/2025

HER2 amplification/mutation in RAS/BRAF wild-type metastatic colorectal cancer is a negative prognostic factor but does not predict differential benefit from bevacizumab or anti-EGFR therapies, based on analysis of 1,604 patients across eight randomized trials.

news Oncology Specialties

Cell-Based Ciliary Neurotrophic Factor Therapy for Macular Telangiectasia Type 2: Clinical Advances and Therapeutic Implications

By MedXY 09/10/2025

Phase 3 trials demonstrate that encapsulated cell therapy NT-501 significantly slows photoreceptor loss in MacTel, marking a promising disease-modifying approach with an acceptable safety profile.