Hepatic Arterial Infusion of Floxuridine Plus Systemic Gemcitabine–Cisplatin Substantially Improves Survival for Liver‑Confined Unresectable Intrahepatic Cholangiocarcinoma: PUMP‑2 Trial Results
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Hepatic Arterial Infusion of Floxuridine Plus Systemic Gemcitabine–Cisplatin Substantially Improves Survival for Liver‑Confined Unresectable Intrahepatic Cholangiocarcinoma: PUMP‑2 Trial Results

The PUMP‑2 phase II trial reports that hepatic arterial infusion (HAIP) of floxuridine combined with systemic gemcitabine–cisplatin achieved a 1‑year overall survival of 80% and median OS of 22.3 months in unresectable liver‑confined intrahepatic cholangiocarcinoma, surpassing historical gem‑cis cohorts.
Ifinatamab Deruxtecan Hiển Thị Hoạt Động Hứa Hẹn ở Bệnh Phổi Tiểu Hạt Diện Rộng Đã Điều Trị Trước: Phân Tích Chính của Thử Nghiệm Giai Đoạn II IDeate-Lung01
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Ifinatamab Deruxtecan Hiển Thị Hoạt Động Hứa Hẹn ở Bệnh Phổi Tiểu Hạt Diện Rộng Đã Điều Trị Trước: Phân Tích Chính của Thử Nghiệm Giai Đoạn II IDeate-Lung01

Trong thử nghiệm giai đoạn II IDeate-Lung01, ifinatamab deruxtecan (I-DXd) liều 12 mg/kg mỗi 3 tuần đã đạt tỷ lệ đáp ứng khách quan xác nhận (ORR) là 48,2% và thời gian sống không tiến triển trung bình (PFS) là 4,9 tháng ở bệnh phổi tiểu hạt diện rộng đã điều trị trước (ES-SCLC), với tỷ lệ bệnh phổi kẽ liên quan đến điều trị được đánh giá là 12,4%. Kết quả hỗ trợ phát triển tiếp theo với việc giám sát cẩn thận bệnh phổi kẽ.
Ifinatamab Deruxtecan Shows Promising Activity in Previously Treated Extensive‑Stage SCLC: Primary Analysis of Phase II IDeate‑Lung01
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Ifinatamab Deruxtecan Shows Promising Activity in Previously Treated Extensive‑Stage SCLC: Primary Analysis of Phase II IDeate‑Lung01

In the phase II IDeate‑Lung01 trial, ifinatamab deruxtecan (I‑DXd) at 12 mg/kg every 3 weeks produced a confirmed ORR of 48.2% and median PFS 4.9 months in heavily pretreated extensive‑stage small cell lung cancer (ES‑SCLC), with an adjudicated treatment‑related ILD rate of 12.4%. Results support further development with careful ILD monitoring.
Paracetamol Lowers Cerebral Temperature Modestly but Meaningfully in Febrile Brain‑Injured Patients: Results of the NEUROTHERM Randomized Pharmacodynamic Trial
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Paracetamol Lowers Cerebral Temperature Modestly but Meaningfully in Febrile Brain‑Injured Patients: Results of the NEUROTHERM Randomized Pharmacodynamic Trial

In a double‑blind RCT of 99 febrile brain‑injured patients with intracerebral thermal probes, a single IV dose of paracetamol reduced mean cerebral temperature by 0.6°C versus placebo and kept cerebral temperature <38.5°C for a median 3.6 hours; one‑third of patients did not respond.
Ruxolitinib Improves Failure-Free and Overall Survival Versus Best Available Therapy in Steroid-Refractory Acute GVHD: Final 24‑Month REACH2 Analysis
Posted inHematology-Oncology news Transplantation

Ruxolitinib Improves Failure-Free and Overall Survival Versus Best Available Therapy in Steroid-Refractory Acute GVHD: Final 24‑Month REACH2 Analysis

The 24‑month final analysis of the phase III REACH2 trial shows ruxolitinib produced longer failure‑free survival, improved median overall and event‑free survival, and a longer duration of response versus best available therapy (BAT) in patients with steroid‑refractory acute GVHD.
Nurse-Led Family Communication in the ICU: Modest Gains in Communication Quality and Shorter Hospital Stays — What Works and What We Still Don’t Know
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Nurse-Led Family Communication in the ICU: Modest Gains in Communication Quality and Shorter Hospital Stays — What Works and What We Still Don’t Know

A 2025 systematic review of nurse-led ICU family communication interventions found modest improvement in communication quality (SMD 0.26) and reduced hospital LOS (~3.9 days), but limited effects on psychological distress, satisfaction, ICU LOS, or mortality. Heterogeneity in models and implementers limits firm recommendations.
Five-Year ZUMA-5 Follow-Up: Durable Remissions and Potential for Cure with Axicabtagene Ciloleucel in Relapsed/Refractory Follicular Lymphoma
Posted inHematology-Oncology news Oncology

Five-Year ZUMA-5 Follow-Up: Durable Remissions and Potential for Cure with Axicabtagene Ciloleucel in Relapsed/Refractory Follicular Lymphoma

Five-year outcomes from ZUMA-5 show axi-cel produces high response rates in relapsed/refractory indolent NHL, with 75% CR, median PFS ~62 months, durable remissions linked to early CAR T expansion and naïve T-cell product phenotype, and an acceptable long-term safety profile.
Carboplatin in Neoadjuvant Chemotherapy for Triple‑Negative Breast Cancer: No EFS Gain but an Overall Survival Signal Driven by Premenopausal Patients
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Carboplatin in Neoadjuvant Chemotherapy for Triple‑Negative Breast Cancer: No EFS Gain but an Overall Survival Signal Driven by Premenopausal Patients

A phase III trial found that adding weekly carboplatin to taxane‑anthracycline neoadjuvant chemotherapy did not significantly improve event‑free survival overall but was associated with improved overall survival, with benefits concentrated in premenopausal women; hematologic toxicity increased.
Home-Based Prehabilitation Did Not Reduce Disability or Complications in Older Adults with Frailty: Results of a Pragmatic Multicenter RCT
Posted inAnesthesiology General Surgery news Rehabilitation Medicine

Home-Based Prehabilitation Did Not Reduce Disability or Complications in Older Adults with Frailty: Results of a Pragmatic Multicenter RCT

A pragmatic multicenter randomized trial found that coach-supported, home-based multimodal prehabilitation before elective noncardiac surgery did not reduce 30-day postoperative disability or in-hospital complications in older adults with frailty; higher adherence signaled possible benefit for disability outcomes.