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Pirfenidone plus Steroids Improves Gas Transfer in Grade 2–3 Radiation‑Induced Lung Injury: Phase 2 Multicentre Randomised Trial
Posted innews Oncology Radiology Respiratory

Pirfenidone plus Steroids Improves Gas Transfer in Grade 2–3 Radiation‑Induced Lung Injury: Phase 2 Multicentre Randomised Trial

Posted by MedXY By MedXY 11/12/2025
A multicentre phase 2 randomised trial found pirfenidone added to standard glucocorticoids improved DLCO% at 24 weeks versus steroids alone in grade 2–3 radiation‑induced lung injury, with manageable safety and no treatment‑related deaths.
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Optimizing Twice-Daily Thoracic Radiotherapy Dosage in Limited-Stage Small-Cell Lung Cancer: Impact on Survival and Toxicity
Posted inClinical Updates news Oncology Radiology Specialties

Optimizing Twice-Daily Thoracic Radiotherapy Dosage in Limited-Stage Small-Cell Lung Cancer: Impact on Survival and Toxicity

Posted by MedXY By MedXY 08/26/2025
A phase II trial reveals that high-dose twice-daily thoracic radiotherapy (60 Gy/40 fractions) significantly improves survival without increasing severe toxicity compared to the standard dose (45 Gy/30 fractions) in limited-stage SCLC patients.
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  • Targeting the Integrin αV-YAP-CTGF Axis: A New Frontier in Treating Congestive Hepatopathy and Liver Carcinogenesis
  • From Pressure to Cancer: Unveiling the Integrin αV-YAP-CTGF Axis as a Therapeutic Target in Congestive Hepatopathy
  • Nerandomilast Shows Potential Mortality Benefit in IPF Despite Neutral Composite Secondary Endpoints: Insights from FIBRONEER-IPF Extended Follow-up
  • Beyond the Clot: Novel Proteomic Markers Redefine Venous Thromboembolism Risk
  • The Cardiovascular-Kidney-Metabolic (CKM) Syndrome Revolution: Mapping Medication Eligibility and Multi-Systemic Benefits
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