Sarcopenia – Medxy AI

AI-Derived Sarcopenia Metrics Predict Survival Benefit from Anti-EGFR Therapy in RAS Wild-Type Metastatic Colorectal Cancer

By MedXY 01/08/2026

A deep learning analysis of the PanaMa trial reveals that the benefit of adding panitumumab to maintenance therapy for RAS wild-type mCRC is significantly higher in patients with a high muscle-bone ratio, suggesting a new AI-driven approach to personalized oncology.

AI news Oncology

Muscle-Bone Ratio: A New AI-Driven Biomarker for Anti-EGFR Response in Metastatic Colorectal Cancer

By MedXY 01/08/2026

A deep learning-derived sarcopenia marker, the muscle-bone ratio (MBR), has been shown to predict the efficacy of anti-EGFR maintenance therapy in patients with RAS wild-type metastatic colorectal cancer, potentially identifying those who truly benefit from treatment intensification.

Internal Medicine news Public Health

Why Our Strength and Fitness Peak in Our 20s–30s — and How Exercise Can Push Back the Clock

By MedXY 12/20/2025

A 47-year study shows physical capacity peaks in the late 20s–30s and accelerates downward from about age 40 — but regular exercise, started at any age, can meaningfully delay decline.

news Orthopedics Rheumatology

Baseline Sarcopenia Predicts Faster Knee Osteoarthritis Progression and Much Higher Risk of Knee Replacement

By MedXY 11/01/2025

In a longitudinal analysis of 4,316 Osteoarthritis Initiative participants, baseline sarcopenia screened by SARC-F and chair-stand testing was associated with accelerated radiographic and symptomatic knee OA progression over 24–48 months and substantially higher risk of subsequent knee replacement.

Gastroenterology General Surgery news

Prehabilitation in Sarcopenic Patients Undergoing Major Hepatectomy: Evidence from the PREHEP Trial

By MedXY 10/10/2025

A 6-week multimodal prehabilitation program combining exercise and nutrition significantly reduces postoperative morbidity in sarcopenic patients undergoing major liver resection, highlighting a promising strategy to improve surgical outcomes.