reproductive medicine

Antifibrotic Repurposing: How Finerenone Could Rejuvenate the Ovarian Niche and Restore Fertility in POI

By MedXY 02/07/2026

A breakthrough study in Science reveals that the antifibrotic drug finerenone restores fertility in premature ovarian insufficiency (POI) by reducing ovarian stromal fibrosis, enabling follicle development where hormone therapy previously failed.

news OB/GYN & Women's Health

Does Size Matter? Re-evaluating Endometrial Thickness Thresholds in 30,000 Euploid Embryo Transfers

By MedXY 12/26/2025

An international multicenter study confirms that endometrial thickness below 7 mm reduces live birth rates in most frozen embryo transfer protocols, though the impact is notably absent in natural cycles and overall predictive power remains modest.

news OB/GYN & Women's Health

Challenging the Compaction Paradigm: Why Endometrial Thinning May Not Predict Pregnancy Success in HRT-FET

By MedXY 12/26/2025

A large-scale analysis of over 16,000 cases reveals that endometrial compaction following progesterone administration does not improve pregnancy outcomes in HRT-FET, and may even be associated with lower success rates in blastocyst transfers.

news OB/GYN & Women's Health

Rethinking Mosaicism: Why Reporting Putative Mosaic Embryos Fails to Improve IVF Outcomes

By MedXY 12/24/2025

A large, double-blinded study reveals that reporting embryo mosaicism (ICN) during PGT-A provides no meaningful clinical predictive value for live birth rates, suggesting that current classification systems may unnecessarily limit embryo selection without improving overall success in routine IVF practice.

news

Optimising Ovulation Timing in Intrauterine Insemination: Evidence Still Unclear

By MedXY 12/18/2025

A Cochrane review finds no definitive evidence on the best method to synchronise insemination with ovulation in subfertile couples undergoing IUI.