randomized trial – Medxy AI

Physical Therapy for Degenerative Meniscal Tear: No Added Benefit Over Home Exercise Alone in Knee Pain Management

By MedXY 10/31/2025

A randomized trial shows that physical therapy and text message reminders do not significantly improve knee pain outcomes beyond a simple home exercise program in patients aged 45-85 with degenerative meniscal tears.

news Psychiatry

Comparative Efficacy and Tolerability of Seven Antipsychotics in Acute Schizophrenia: Insights from a Large Multicenter Randomized Trial

By MedXY 10/29/2025

A multicenter randomized trial comparing seven antipsychotics in acute schizophrenia shows olanzapine and risperidone outperform several agents in efficacy but differ markedly in side effects, clarifying treatment choices.

Cardiology Infectious Diseases news

Evaluating Cardiovascular-Focused Messaging to Enhance Influenza Vaccination Uptake in Diverse U.S. Populations

By MedXY 10/03/2025

A large randomized trial in the U.S. found no significant improvement in influenza vaccination rates with cardiovascular-focused messaging compared to usual care, despite prior positive findings in Denmark.

Clinical Updates Internal Medicine OB/GYN & Women's Health Specialties

Evaluating Low-Dose Aspirin for Postpartum Venous Thromboembolism Prevention: Insights from the Pilot PARTUM Trial

By MedXY 09/20/2025

The pilot PARTUM trial demonstrates the feasibility of a large-scale multi-national randomized study assessing low-dose aspirin versus placebo for postpartum venous thromboembolism prevention in moderate-risk individuals, supporting further investigation.

Clinical Updates news OB/GYN & Women's Health Specialties

Aspirin for Delaying Preterm Birth in High-Risk Preterm Pre-eclampsia Pregnancies: Insights from a Multicenter Randomized Trial in Asia

By MedXY 09/19/2025

Early low-dose aspirin reduces early preterm birth risk and delays timing of delivery in women at high risk for preterm pre-eclampsia, with significant benefits in iatrogenic preterm births and small-for-gestational-age pregnancies.

Family Medicine & Nutrition Neurology news Specialties

Unlocking Better Sleep: How Daily Walnut Consumption Enhances Melatonin Metabolism and Sleep Quality in Young Adults

By MedXY 09/16/2025

A randomized crossover trial shows that daily intake of 40 g walnuts increases urinary 6-sulfatoxymelatonin, reduces sleep latency, and improves global sleep quality in young adults, highlighting walnuts' potential as a natural sleep aid.

Clinical Updates Hematology-Oncology Specialties

Oral Realgar-Indigo Naturalis Formula Matches Arsenic Trioxide Efficacy in Non-High-Risk Acute Promyelocytic Leukemia: Insights from a Multicenter Randomized Trial

By MedXY 09/10/2025

A pivotal multicenter randomized trial demonstrates that oral Realgar-Indigo naturalis formula (RIF) combined with ATRA is non-inferior to arsenic trioxide (ATO) plus ATRA, providing a simplified consolidation regimen for non-high-risk APL with excellent 2-year disease-free survival and manageable toxicity.

Cardiology Clinical Updates news Specialties

Minimizing Anesthesia in Transcatheter Aortic Valve Implantation: Insights from the DOUBLE-CHOICE Trial

By MedXY 09/07/2025

The DOUBLE-CHOICE randomized trial demonstrates non-inferiority of isolated local anesthesia versus conscious sedation in transfemoral TAVI, suggesting a safe minimalist anesthesia strategy with potential trade-offs in patient comfort.

Cardiology news Specialties

Cerebral Embolic Protection and Cognitive Outcomes After TAVI: Insights from the BHF PROTECT-TAVI Trial

By MedXY 09/06/2025

The BHF PROTECT-TAVI randomized trial found no cognitive benefit from using cerebral embolic protection devices during transcatheter aortic valve implantation, despite their theoretical role in mitigating embolic brain injury.

Cardiology Neurology news Specialties

Cerebral Embolic Protection Fails to Preserve Cognitive Function After TAVI: Insights from the BHF PROTECT-TAVI Trial

By MedXY 09/06/2025

The BHF PROTECT-TAVI randomized trial reveals that cerebral embolic protection (CEP) devices do not prevent cognitive decline following transcatheter aortic valve implantation (TAVI), challenging assumptions about their neuroprotective benefits.

Family Medicine & Nutrition Orthopedics Specialties

Comparative Effectiveness of Cupping and Scraping Therapy Versus NSAIDs for Chronic Nonspecific Low-Back Pain: Insights from a Multicenter Randomized Trial

By MedXY 08/26/2025

A recent multicenter randomized trial demonstrates superior short-term efficacy of cupping and scraping therapy with medicated balm over NSAIDs with capsaicin plasters in reducing pain and improving quality of life for chronic nonspecific low-back pain.

Dentistry Family Medicine & Nutrition news Plastic Surgery Specialties

Can Kissing Save Your Smile? Exploring Its Potential Protective Role Against Dental Cavities

By MedXY 08/26/2025

New research explores whether kissing can help restore saliva's pH balance after sugary drinks, potentially protecting against dental caries.

Cardiology Clinical Updates Neurology news Specialties

Evaluating Thigh-High Compression Stockings in Preventing Vasovagal Syncope Recurrence: Insights from a Randomized Sham-Controlled Trial

By MedXY 08/17/2025

A randomized sham-controlled trial found that thigh-high elastic compression stockings did not significantly reduce vasovagal syncope recurrence or improve syncope-free survival, though fewer episodes occurred during active stocking use.

AI Clinical Updates Nephrology news Specialties

Evaluating Electronic Nudges to Enhance Guideline-Directed Therapy in Chronic Kidney Disease: Insights from the NUDGE-CKD Trial

By MedXY 08/16/2025

The NUDGE-CKD trial found that electronic letter-based nudges to patients with chronic kidney disease and their general practitioners did not significantly improve initiation of guideline-recommended medications over usual care.

Gastroenterology General Surgery news Specialties

Appendicectomy Plus Medical Therapy Significantly Reduces Relapse in Ulcerative Colitis: Insights from the ACCURE Trial

By MedXY 08/14/2025

The ACCURE trial demonstrates that laparoscopic appendicectomy combined with standard medical therapy significantly lowers 1-year relapse rates compared to medical therapy alone in ulcerative colitis patients in remission.

Clinical Updates Gastroenterology news Psychiatry Specialties

Therapist-Guided Internet CBT Cuts Bulimia Episodes: A Japanese Randomized Trial with Promising Clinical Implications

By MedXY 08/09/2025

A multicenter randomized trial in Japan found that a 12-week therapist-guided internet-based CBT program significantly reduced weekly bingeing and compensatory episodes in women with bulimia nervosa versus usual care (adjusted mean difference 9.84 episodes; Cohen d 0.73).

Critical Care news Specialties

UK-ROX Trial: Conservative Oxygen Strategy in Mechanically Ventilated ICU Patients — No 90‑Day Survival Benefit

By MedXY 08/09/2025

The UK-ROX randomized trial (n=16,500) found that targeting SpO2 90% (88–92%) to reduce oxygen exposure did not reduce 90‑day all‑cause mortality versus usual care in mechanically ventilated adults.

Clinical Updates Family Medicine & Nutrition Neurology news Pediatrics Specialties

Ketogenic Diet vs Further Antiseizure Medication in Infants with Drug-Resistant Epilepsy: What the KIWE Trial Adds to Clinical Practice

By MedXY 08/09/2025

The KIWE randomised trial (Lancet Neurol 2023) found no superiority of a classic ketogenic diet over an additional antiseizure medication for seizure frequency in infants (1–24 months) with drug‑resistant epilepsy; tolerability and safety profiles were similar, supporting the diet as a viable treatment option.

Clinical Updates news Orthopedics Specialties

Exercise Alone Matches Diet Plus Exercise for Hip Osteoarthritis Pain Relief, Large Randomized Trial Shows

By MedXY 08/04/2025

Adding a very-low-calorie diet to exercise yields no additional pain relief for overweight or obese adults with hip osteoarthritis, despite greater weight loss.

Clinical Updates Infectious Diseases news Specialties Urology

Individualised Versus Standard 10-Day Antibiotic Therapy in Pediatric Febrile UTI: Insights from the INDI-UTI Trial

By MedXY 08/02/2025

A Danish multicentre trial found individualised, shorter antibiotic regimens for febrile pediatric UTIs reduce overall antibiotic exposure and adverse events, but with a modestly higher recurrence risk compared to standard 10-day treatment.