randomized controlled trials

Lithium’s Role in Reducing Suicidal Ideation and Behaviors: An Updated Meta-Analysis of Randomized Controlled Trials

By MedXY 10/12/2025

This systematic review evaluates lithium’s efficacy in reducing suicidal ideation, attempts, and completed suicide, highlighting methodological challenges and the likelihood of benefit despite lack of statistical significance in RCTs.

Gastroenterology Neurology news

Probiotics and Cognitive Health: Evaluating the Evidence from Systematic Reviews and Meta-Analyses

By MedXY 10/12/2025

An umbrella review synthesizes evidence from 156 RCTs assessing probiotics' effects on cognitive-related outcomes, showing moderate- to high-quality support for cognitive benefits but highlighting need for further trials on strains and dosing.

Gastroenterology Infectious Diseases news

Proton Pump Inhibitors and Clostridioides difficile Infection: A Comprehensive Meta-Analysis of Randomized Controlled Trials Reveals No Increased Risk

By MedXY 10/11/2025

This systematic review and meta-analysis of randomized controlled trials finds no significant association between proton pump inhibitor use and increased risk of Clostridioides difficile infection, challenging earlier observational data and supporting their safety in clinical practice when appropriately prescribed.

Cardiology Clinical Updates Family Medicine & Nutrition news Specialties

Dietary Approaches to Stop Hypertension (DASH) for the Primary and Secondary Prevention of Cardiovascular Diseases: A Systematic Review of Randomised Controlled Trials

By MedXY 08/26/2025

This review evaluates the DASH diet's impact on major cardiovascular outcomes, synthesizing evidence from RCTs and highlighting its benefits on blood pressure and lipid profiles amid gaps in long-term clinical outcome data.

AI General Surgery Specialties

Virtual Reality for Reducing Preoperative Anxiety: Insights from Cardiac Surgery Trials and Meta-Analyses of Elective Surgical Procedures

By MedXY 08/21/2025

Virtual reality (VR) interventions show promise in mitigating preoperative anxiety, with clinical trials and meta-analyses indicating moderate but significant anxiolytic effects across surgical populations, especially in cardiac surgery and pediatric patients.

AI Diabetes & Endocrinology news Specialties

Harnessing Digital Health Technologies in Obesity Management: Insights from a Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Trials

By MedXY 08/18/2025

Digital health interventions show modest but clinically meaningful reductions in waist circumference for overweight and obese adults, highlighting their potential as adjuncts in obesity care despite limited effects on weight and behavior.