Biopsychosocial Self-Management Superior to Standard Care for Reducing Disability in Acute Back Pain: Insights from the PACBACK Trial
Posted inFamily Medicine & Nutrition news Orthopedics

Biopsychosocial Self-Management Superior to Standard Care for Reducing Disability in Acute Back Pain: Insights from the PACBACK Trial

The PACBACK randomized trial reveals that clinician-supported biopsychosocial self-management significantly reduces one-year disability in patients with acute low back pain at high risk of chronicity, whereas spinal manipulation alone offers no significant advantage over standard medical care.
Tailored Weight Loss Interventions for Veterans with Serious Mental Illness: Efficacy and Implementation Insights from Recent RCT Evidence
Posted inClinical Updates Internal Medicine news Psychiatry

Tailored Weight Loss Interventions for Veterans with Serious Mental Illness: Efficacy and Implementation Insights from Recent RCT Evidence

This review synthesizes evidence from a 2025 randomized clinical trial evaluating a tailored weight loss program, CoachToFit, for veterans with serious mental illness, highlighting its potential to improve weight outcomes via remote support technologies and peer-led interventions.
Evaluating Electromagnetic Network-Targeted Field Therapy for Post-Ischemic Stroke Disability: Insights from the EMAGINE Trial
Posted inNeurology news Rehabilitation Medicine Specialties

Evaluating Electromagnetic Network-Targeted Field Therapy for Post-Ischemic Stroke Disability: Insights from the EMAGINE Trial

The EMAGINE randomized clinical trial assessed low-intensity electromagnetic stimulation combined with rehabilitation in moderate to severe ischemic stroke patients. While safe, it did not yield statistically significant functional improvement, warranting further investigation.
High-Dose vs Standard-Dose Influenza Vaccine and Cardiovascular Outcomes in Older Adults: Insights from the DANFLU-2 Randomized Clinical Trial and Related Evidence
Posted inCardiology Public Health Specialties

High-Dose vs Standard-Dose Influenza Vaccine and Cardiovascular Outcomes in Older Adults: Insights from the DANFLU-2 Randomized Clinical Trial and Related Evidence

This review synthesizes evidence on high-dose versus standard-dose influenza vaccines for cardiovascular outcomes in older adults, focusing on the large DANFLU-2 trial and complementary studies, highlighting modest cardiovascular benefits and implications for clinical practice.
Evaluating the 23-Valent Pneumococcal Polysaccharide Vaccine for Cardiovascular Event Prevention: Insights from a Landmark Randomized Trial
Posted innews Public Health Respiratory

Evaluating the 23-Valent Pneumococcal Polysaccharide Vaccine for Cardiovascular Event Prevention: Insights from a Landmark Randomized Trial

A large randomized clinical trial demonstrated that the 23-valent pneumococcal polysaccharide vaccine (PPV23) did not significantly reduce fatal or nonfatal acute coronary syndrome and ischemic stroke among middle-aged adults at increased cardiovascular risk over seven years of follow-up.
Ammoxetine Shows Promise as Effective and Well-Tolerated Treatment for Major Depressive Disorder: Insights from a Phase 2 Randomized Trial
Posted inClinical Updates news Psychiatry

Ammoxetine Shows Promise as Effective and Well-Tolerated Treatment for Major Depressive Disorder: Insights from a Phase 2 Randomized Trial

A phase 2 trial in adults with major depressive disorder demonstrated that ammoxetine at 40 mg/d and 60 mg/d significantly improved depressive symptoms compared to placebo and was generally well tolerated, offering a novel treatment option with potentially fewer adverse effects.