Proton Craniospinal Irradiation Improves CNS Progression-Free and Overall Survival in Leptomeningeal Metastasis: Randomized Phase 2 Evidence
In a randomized phase 2 trial, proton craniospinal irradiation (pCSI) significantly improved central nervous system progression‑free survival and overall survival versus involved‑field photon radiotherapy in patients with leptomeningeal metastasis from solid tumors.