preterm infants – Medxy AI

Rethinking Oxygen Strategies for Preterm Infant Resuscitation: Evidence from TORPIDO, IPD-MA, and DCC Trials

By MedXY 12/16/2025

Recent trials and meta-analyses challenge assumptions about optimal initial oxygen levels for preterm resuscitation.

news Pediatrics

Supplemental Donor Human Milk Did Not Speed Full Enteral Feeding in Moderate–Late Preterm Infants: Results From a Multisite Randomized Trial

By MedXY 12/14/2025

In a blinded multisite RCT of 201 moderate–late preterm infants, short-term supplementation with pasteurized donor human milk versus term formula did not shorten time to full enteral feeds; donor milk was associated with slower regain of birth weight.

Cardiology news Pediatrics

Expectant Management Improves Early Survival Without Increasing BPD: Results from the PDA Randomized Clinical Trial

By MedXY 12/12/2025

In extremely preterm infants with a protocol-defined PDA, expectant management yielded similar rates of death or BPD at 36 weeks’ postmenstrual age but significantly higher survival compared with active pharmacologic closure.

Clinical Updates news Pediatrics Respiratory

Hydrocortisone in Preterm Infants and School-Age Functional Outcomes: Comprehensive Review of Evidence from Randomized Clinical Trials

By MedXY 12/08/2025

Neonatal hydrocortisone treatment in preterm infants at high risk for bronchopulmonary dysplasia does not improve school-age functional outcomes, highlighting the persistent burden of developmental impairment despite intervention.

Hematology-Oncology Pediatrics Specialties

Personalized Prediction of Platelet Transfusion Outcomes in Preterm Infants with Severe Thrombocytopenia

By MedXY 10/14/2025

A dynamic model predicts individualized risk of major bleeding or death with or without prophylactic platelet transfusion in preterm infants, allowing tailored clinical decisions based on evolving patient status.

news Pediatrics Respiratory

Evaluating Early Intratracheal Budesonide to Reduce Bronchopulmonary Dysplasia in Extremely Preterm Infants: Insights from the BiB Randomized Clinical Trial

By MedXY 10/10/2025

The BiB trial showed that adding budesonide to surfactant did not reduce bronchopulmonary dysplasia or death in extremely preterm infants but was associated with increased hyperglycemia risk.

news Pediatrics Specialties

Enhanced Respiratory Support in Very Preterm Infants: Nasal Mask CPAP Outperforms Face Mask at Birth

By MedXY 09/21/2025

An open-label RCT demonstrates that nasal mask CPAP at birth increases CPAP success rates and reduces the need for positive pressure ventilation compared to face mask CPAP in very preterm infants, with comparable safety profiles.

Clinical Updates news Pediatrics Specialties

Deferred Cord Clamping with High Oxygen in Extremely Preterm Infants: Enhancing Early Oxygenation Without Added Morbidity

By MedXY 09/10/2025

This review examines randomized clinical evidence that 100% oxygen during deferred cord clamping improves early oxygen saturation in extremely preterm infants without increasing morbidity, highlighting implications for neonatal resuscitation practice.

Clinical Updates news Pediatrics Specialties

Darbepoetin in Preterm Infants: Enhancing Red Cell Mass without Neurodevelopmental Benefit

By MedXY 08/04/2025

Weekly darbepoetin in extremely preterm infants increases red cell mass and reduces transfusion needs, but does not improve cognitive outcomes at 22-26 months' corrected age.

Clinical Updates Family Medicine & Nutrition news Pediatrics Specialties

Supplemental Donor Milk versus Infant Formula for Moderate to Late Preterm Infants: Implications from a Multisite Randomized Trial

By MedXY 08/04/2025

A multisite RCT found no difference in time to full enteral feeds between donor human milk and formula in moderate to late preterm infants, but formula was associated with faster weight regain.

Clinical Updates news

Perinatal Antibiotic Exposure Alters Neonatal Gut Microbiota in Preterm Infants: Clinical Implications for Infection Risk and Microbial Maturation

By MedXY 08/04/2025

Perinatal antibiotic exposure in preterm infants disrupts gut microbiota composition, increasing pathogenic bacteria and reducing beneficial species, with implications for infection risk and the protective role of breastfeeding.