Percutaneous Coronary Intervention

The 30-Day Ischemic Penalty: Why Early Aspirin Withdrawal in ACS Requires Caution

By MedXY 01/03/2026

A landmark analysis from the NEOMINDSET trial demonstrates that while potent P2Y12 inhibitor monotherapy reduces bleeding, it significantly increases ischemic risk in the first 30 days after PCI for acute coronary syndrome, suggesting that the timing of aspirin withdrawal is critical for patient safety.

Cardiology Clinical Updates news

Advances in Optical Coherence Tomography-Guided Coronary Stenting: Insights from the ILUMIEN IV Trial and Related Studies

By MedXY 11/29/2025

OCT-guided PCI enhances procedural outcomes and reduces adverse events in complex and calcified coronary lesions compared with angiography guidance, with emerging physiological assessment tools improving prognostic accuracy.

Cardiology news

NOAC Monotherapy After Drug‑Eluting Stent: Safer and at Least as Effective as NOAC Plus Clopidogrel in AF Patients ≥1 Year After PCI

By MedXY 11/10/2025

In the ADAPT AF‑DES randomized trial, NOAC monotherapy in AF patients with drug‑eluting stents implanted ≥1 year earlier reduced bleeding and was noninferior—and numerically superior—for a composite of ischemic and bleeding outcomes versus NOAC plus clopidogrel at 12 months.

Cardiology news

Immediate vs Deferred PCI for Nonculprit Lesions in STEMI: Insights from the iMODERN Trial

By MedXY 10/31/2025

The iMODERN trial demonstrates that immediate iFR-guided PCI of nonculprit lesions in STEMI patients offers no significant benefit over deferred stress MRI-guided PCI regarding major cardiac events at 3 years.

Cardiology Clinical Updates Nephrology

Exploring the Impact of Reduced Left Ventricular Function on Outcomes After PCI in Chronic Kidney Disease Patients

By MedXY 09/27/2025

Reduced left ventricular ejection fraction (LVEF) adversely affects survival and myocardial infarction risk in patients with chronic kidney disease undergoing percutaneous coronary intervention, despite no significant difference in overall major cardiovascular events.

Cardiology Radiology Specialties

Long-Term Comparative Outcomes of FFR vs IVUS-Guided PCI in Intermediate Coronary Stenosis: Insights from the FLAVOUR Trial Extended Follow-Up

By MedXY 08/22/2025

The FLAVOUR trial's extended 6.3-year follow-up shows equivalent long-term outcomes for FFR- and IVUS-guided PCI strategies in intermediate coronary stenosis, with FFR associated with fewer total PCIs but slight increases in late revascularization.

Cardiology Specialties

Decade-Long Insights into Deferred Versus Immediate Stenting in STEMI Patients: DANAMI-3-DEFER Trial Findings

By MedXY 08/17/2025

The 10-year DANAMI-3-DEFER study compared deferred stenting to immediate stenting in STEMI, showing no mortality benefit but reduced heart failure hospitalizations with deferred stenting.

Cardiology Clinical Updates Nephrology news Specialties

Delayed Remote Ischemic Preconditioning Reduces Contrast-Associated Acute Kidney Injury After Coronary Angiography and PCI: Insights from a Randomized Trial

By MedXY 08/13/2025

A multicenter randomized trial demonstrates that delayed remote ischemic preconditioning 24 hours prior to coronary angiography or PCI significantly lowers the incidence of contrast-associated acute kidney injury in high-risk patients.