Parkinson disease

Sustained Symptom Control over Five Years: Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson Disease

By MedXY 09/26/2025

Five-year follow-up from the INTREPID trial confirms that subthalamic nucleus deep brain stimulation significantly improves motor symptoms, reduces dyskinesia, lowers medication needs, and enhances daily living activities in moderate to advanced Parkinson disease patients, with an acceptable safety profile.

Clinical Updates Neurology news Specialties Urology

Behavioral Therapy Matches Drug Efficacy for Overactive Bladder in Parkinson’s Disease: Insights from a Randomized Noninferiority Trial

By MedXY 09/11/2025

A 12-week randomized trial demonstrates that behavioral therapy is noninferior to solifenacin in treating overactive bladder symptoms in Parkinson disease, with fewer adverse effects, supporting behavioral therapy as a frontline treatment option.

Clinical Updates Family Medicine & Nutrition Neurology news Radiology Specialties

Physical Exercise Slows Neurodegeneration and Cognitive Decline in Early Parkinson Disease: Insights from Longitudinal MRI Analysis

By MedXY 08/24/2025

Regular physical activity in early Parkinson disease patients is linked to slower brain atrophy in temporoparietal and limbic regions, mediating better preservation of memory and attention over four years.

Neurology news Specialties

Association of Medication Use and 8-Year Mortality Risk in Patients With Parkinson Disease

By MedXY 08/17/2025

This study explores medication use and its impact on 8-year mortality among patients with Parkinson disease, identifying potential drug repurposing candidates for treatment.