opioid use disorder

Optimizing Opioid Use Disorder Treatment: When Does 300 mg Outperform 100 mg of Extended-Release Buprenorphine?

By MedXY 12/21/2025

This randomized clinical trial compares 100-mg and 300-mg maintenance doses of extended-release buprenorphine. While overall efficacy was similar, the 300-mg dose significantly improved abstinence among patients with high-frequency fentanyl use, suggesting a need for dose-intensification in the era of potent synthetic opioids.

news Psychiatry Public Health

High-Dose Extended-Release Buprenorphine: A Targeted Strategy for the Fentanyl-Driven Opioid Crisis

By MedXY 12/20/2025

This randomized clinical trial compares 100-mg versus 300-mg maintenance doses of extended-release buprenorphine. While overall efficacy was similar, the 300-mg dose significantly improved abstinence rates among heavy fentanyl users, offering a potential pathway for personalized treatment in high-risk populations.

Family Medicine & Nutrition news Psychiatry

Collaborative Care for OUD in Primary Care Reduces Opioid Use: Cluster RCT Shows Added Benefit from an OUD-Focused Model

By MedXY 11/14/2025

A pragmatic cluster randomized trial found that adding OUD-specific components to collaborative care in primary care clinics reduced days of opioid use more than collaborative care for mental health alone, without clear additional mental health benefit over 6 months.

news Psychiatry

Treatment Retention in Opioid Use Disorder During Pregnancy: Buprenorphine vs Methadone Discontinuation Patterns

By MedXY 10/30/2025

This nationwide cohort study reveals higher discontinuation rates of buprenorphine than methadone during pregnancy and up to one year postpartum, highlighting significant challenges in treatment retention for opioid use disorder in pregnant patients.

news Public Health Specialties

Hospital Addiction Consult Services: A Promising Step to Reduce Emergency Visits Among Patients with Opioid Use Disorder

By MedXY 09/11/2025

A hospital-based addiction consult program lowered emergency department visits in opioid use disorder patients but did not reduce hospitalizations or mortality, highlighting the need for comprehensive care beyond hospital walls.

Psychiatry Specialties

Evaluating the Role of Behavioral Therapy in Enhancing Buprenorphine Treatment Outcomes for Opioid Use Disorder: Insights from a Secondary Analysis of Four Randomized Clinical Trials

By MedXY 09/11/2025

A secondary analysis of four randomized trials reveals that additional behavioral therapy does not significantly improve opioid abstinence, retention, or functional outcomes when added to buprenorphine and medical management in opioid use disorder treatment.

Clinical Updates news Psychiatry Specialties

Enhancing Opioid Use Disorder Care in Primary Settings: Impact of an EHR-Integrated Clinical Decision Support System

By MedXY 09/11/2025

A cluster randomized trial demonstrates that an electronic health record–integrated clinical decision support system increases naloxone prescriptions and opioid use disorder treatments in primary care but does not change diagnosis rates or MOUD adherence.

Clinical Updates Medical News Psychiatry Specialties

Synthetic Opioid Overdose Deaths Among Youth Surge 168%: A Five-Year Analysis and Clinical Implications

By MedXY 07/29/2025

Overdose deaths from synthetic opioids alone in U.S. youth aged 15–24 surged 168% between 2018 and 2022, now representing one-third of all youth OD fatalities. Clinical vigilance, harm reduction, and targeted prevention are urgently needed.