NAFLD – Medxy AI

Linarin as a Multifaceted Therapeutic Agent for NAFLD: Modulation of PI3K/Akt/mTOR, Autophagy, and Gut Microbiota

By MedXY 09/07/2025

Linarin shows promise in mitigating NAFLD by enhancing autophagy via PI3K/Akt/mTOR inhibition, reducing inflammation, and restoring gut microbiota balance, alongside activating the PDE4D/cAMP/PKA/CREB pathway to improve hepatic lipid metabolism and oxidative stress.

Clinical Updates Wellness & Lifestyle

Dapagliflozin Shows Promising Benefits for Patients with Metabolic Dysfunction-Associated Steatohepatitis (MASH): A Landmark Multicentre Trial

By MedXY 08/13/2025

Dapagliflozin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis outcomes without increasing adverse events, according to a rigorous 48-week randomized trial.

Clinical Updates Wellness & Lifestyle

Intermittent Calorie Restriction: A Promising Dietary Strategy for Metabolic Dysfunction-Associated Steatotic Liver Disease

By MedXY 08/08/2025

Recent trials show intermittent calorie restriction (ICR) significantly reduces liver fat content in MASLD and NAFLD, especially in obese patients, offering an effective and well-tolerated alternative to conventional diets.

Clinical Updates Wellness & Lifestyle

Pomegranate Peel Extract: A Promising Adjunct in Non-Alcoholic Fatty Liver Disease Management?

By MedXY 08/08/2025

A double-blind RCT suggests pomegranate peel extract may improve liver enzymes, lipid profile, and inflammation in NAFLD patients, but does not significantly alter liver steatosis grade.

Clinical Updates Wellness & Lifestyle

Flaxseed Powder Supplementation: Emerging Evidence in Non-Alcoholic Fatty Liver Disease and Metabolic Health

By MedXY 08/08/2025

Flaxseed powder supplementation shows promise in improving liver fat, lipid metabolism, and inflammation in NAFLD and related metabolic disorders, with effects on gut microbiota but limited synergism with fasting mimicking diets.

Clinical Updates Wellness & Lifestyle

Empowering Community Liver Health: Insights from the LOCATE-NAFLD Trial on Nurse-Led MASLD Screening

By MedXY 08/08/2025

The LOCATE-NAFLD trial demonstrates that nurse-delivered, community-based liver screening is highly acceptable and effective for identifying high-risk MASLD patients, but faces challenges in sustainable adoption.