Endothelial Glycocalyx Degradation in Sepsis: Insights from the CLOVERS Trial on Fluid Resuscitation Strategies and Mortality

Endothelial Glycocalyx Degradation in Sepsis: Insights from the CLOVERS Trial on Fluid Resuscitation Strategies and Mortality

This article reviews findings from the CLOVERS trial analyzing endothelial glycocalyx degradation in sepsis, demonstrating its strong association with mortality but showing no impact of liberal versus restrictive fluid resuscitation strategies on glycocalyx integrity or survival outcomes.
Surgical Management of Left-Sided Infective Endocarditis: Insights from the Nationwide NIDUS Registry

Surgical Management of Left-Sided Infective Endocarditis: Insights from the Nationwide NIDUS Registry

A nationwide Danish study reveals that while 40% of left-sided infective endocarditis patients have surgical indications, only half undergo surgery. Those receiving surgery are younger, less comorbid, and show improved survival, underscoring the need for refined risk assessment in high-risk cases.
Global Impact of Cardiovascular Risk Factors on Lifetime Cardiovascular Disease Burden and Mortality: A Comprehensive Evidence Synthesis

Global Impact of Cardiovascular Risk Factors on Lifetime Cardiovascular Disease Burden and Mortality: A Comprehensive Evidence Synthesis

This review integrates data from over two million individuals globally, showing that absence of five key cardiovascular risk factors at age 50 confers a life expectancy advantage exceeding a decade, with midlife modification of hypertension and smoking yielding substantial gains in disease-free survival and overall longevity.