major depressive disorder

Soft Drink Consumption and Depression: The Gut Microbiome Connection, Especially Eggerthella

By MedXY 09/28/2025

This analysis explores how soft drink consumption correlates with major depressive disorder (MDD), revealing gut microbiome alterations—particularly in Eggerthella abundance—that may mediate this association, highlighting potential intervention targets.

Clinical Updates Wellness & Lifestyle

Ammoxetine Shows Promise as Effective and Well-Tolerated Treatment for Major Depressive Disorder: Insights from a Phase 2 Randomized Trial

By MedXY 09/23/2025

A phase 2 trial in adults with major depressive disorder demonstrated that ammoxetine at 40 mg/d and 60 mg/d significantly improved depressive symptoms compared to placebo and was generally well tolerated, offering a novel treatment option with potentially fewer adverse effects.

Clinical Updates Wellness & Lifestyle

Harnessing AI for Personalized Depression Treatment: Insights from the AID-ME Cluster Randomized Trial

By MedXY 09/14/2025

The AID-ME trial demonstrates that an AI-powered clinical decision support system significantly improves remission rates and accelerates symptom improvement in moderate to severe major depressive disorder.

Clinical Updates Wellness & Lifestyle

Accelerating Depression Recovery: The Impact of Measurement-Based Care in Pakistan’s Low-Resource Settings

By MedXY 09/13/2025

A randomized clinical trial in Pakistan demonstrates that measurement-based care accelerates antidepressant treatment response and remission in major depressive disorder compared to standard care, underscoring its potential in low-resource settings.

Clinical Updates Wellness & Lifestyle

Optimizing Smoking Cessation in Major Depressive Disorder: Varenicline Outperforms Bupropion and Nicotine Patch with Comparable Safety

By MedXY 08/28/2025

This analysis reveals that varenicline is the most effective and safe pharmacotherapy for smoking cessation in individuals with current or past major depressive disorder, outperforming bupropion and nicotine patches with no increased neuropsychiatric risks.

Clinical Updates Wellness & Lifestyle

Exploring Over-the-Counter Herbal and Nutritional Products for Adult Depression: A Comprehensive Evidence Landscape

By MedXY 08/18/2025

A scoping review of 209 trials reveals a concentrated evidence base for omega-3s, St John’s Wort, saffron, probiotics, and vitamin D in treating adult depression, highlights promising but under-researched herbal and supplement candidates, and underscores the need for improved safety reporting and integrative therapy evaluations.